Amphiphilic linear-dendritic triblock copolymers composed of poly(amidoamine) and poly(propylene oxide) and their micellar-phase and encapsulation properties
Amphiphilic linear-dendritic triblock copolymers composed of poly(amidoamine) and poly(propylene oxide) and their micellar-phase and encapsulation properties
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DOI：
10.1021/la0607050
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发表时间：
2006-08-29
期刊：
影响因子：
3.9
通讯作者：
Hammond, Paula T.
中科院分区：
文献类型：
--
作者：
Nguyen, Phuong M.;Hammond, Paula T.
合成了一种由聚胺胺和聚环氧丙烷组成的新型两亲性ABA树状-线状-枝状嵌段共聚物。研究了嵌段共聚物的固相行为与枝晶嵌段的生成、离子强度和溶液ph的关系。三嵌段共聚物在水介质中自组装形成稳定的胶束，其CMC值在10（-6）至10(-5)m之间。动态光散射结果表明，形成的颗粒直径在9至18 nm之间，越长，粒径越小。另外还进行了一些实验来评估纳米颗粒用于药物递送应用的可行性。用模型疏水药物三氯生进行了载药研究，结果表明载药效率在79%至86% w/w之间。由于其在水溶液中的相对稳定性和药物的包封和释放特性，所合成的树突-线状-树突嵌段共聚物是一种很有前途的药物递送候选材料。
A novel amphiphilic ABA dendritic-linear-dendritic block copolymer consisting of poly( amidoamine) and poly( propylene oxide) has been synthesized. The solution-phase behavior of the block copolymer was studied as a function of the generation of the dendritic block, ionic strength, and solution pH. The triblock self-assembles in aqueous media to form stable micelles with CMC values ranging from 10(-6) to 10(-5) M. Dynamic light scattering results indicate the formation of particles ranging from 9 to 18 nm in diameter, with smaller diameters exhibited at higher generations. Additional experiments were performed to assess the feasibility of the nanoparticles for drug delivery applications. Drug loading studies were performed with a model hydrophobic drug, triclosan, resulting in high loading efficiencies ranging from 79 to 86% w/w. The dendritic-linear-dendritic block copolymer synthesized was found to be a promising candidate for drug delivery due to its relative stability in aqueous solution and its drug encapsulation and release properties.