ARCHITECTURE, COMPOSITION, AND CONTRACTILE PROPERTIES OF RAT SOLEUS MUSCLE GRAFTS
ARCHITECTURE, COMPOSITION, AND CONTRACTILE PROPERTIES OF RAT SOLEUS MUSCLE GRAFTS
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DOI：
10.1152/ajpcell.1986.250.3.c474
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发表时间：
1986-03-01
影响因子：
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通讯作者：
FAULKNER, JA
中科院分区：
文献类型：
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作者：
SEGAL, SS;WHITE, TP;FAULKNER, JA
与对照组相比，骨骼肌移植物在张力发展方面存在缺陷，即使在考虑到质量和总肌肉横截面积减少后。我们的目的是确定大鼠比目鱼肌移植物的结构，组织成分和收缩性能之间的关系。将数据与从同窝仔获得的对照比目鱼肌进行比较。雌性Wistar大鼠用戊巴比妥钠麻醉，进行比目鱼肌神经移植和移植后56天的肌肉解剖。与对照值相比，移植物的最大比张力（N/cm 2）为76%，间质（菊粉）空间为135%，结缔组织蛋白浓度为177%。对于移植物，总肌肉长度和纤维分别为对照值的91%和123%。移植物在零载荷下的外推缩短速度（纤维长度/s）与对照值没有差异。移植物比张力的不足是由于非收缩性组织成分浓度较高。移植后肌肉结构和组成的变化对收缩动力学影响不大。
Skeletal muscle grafts have a deficit in tension development compared with control muscles, even after accounting for reduced mass and total muscle cross-sectional area. Our purpose was to determine relationships among the architecture, tissue composition, and contractile properties of rat soleus muscle grafts. Data were compared with control soleus muscles obtained from littermates. Female Wistar rats were anesthetized with pentobarbital sodium for grafting of soleus muscles with nerve implant and for dissection of muscles 56 days after grafting. Compared with control values, the maximum specific tension (N/cm2) of grafts was 76%, the interstitial (inulin) space was 135%, and the connective tissue protein concentration was 177%. For grafts, total muscle length and fiber were 91 and 123% of control values, respectively. The extrapolated shortening velocity at zero load (fiber lengths/s) for grafts was not different from the control value. The deficit in specific tension of grafts is explained by a greater concentration of noncontractile tissue components. Changes in muscle architecture and composition following grafting had little effect on contraction dynamics.