Role of natural interferon-alpha producing cells (plasmacytoid dendritic cells) in autoimmunity.
Role of natural interferon-alpha producing cells (plasmacytoid dendritic cells) in autoimmunity.
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发表时间：
2003
期刊：
影响因子：
3.5
通讯作者：
L. Rönnblom;M. Eloranta;G. Alm
中科院分区：
文献类型：
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作者：
L. Rönnblom;M. Eloranta;G. Alm
I型干扰素（IFN）具有抗病毒、抑制细胞生长和显著的免疫调节作用，这些作用在病毒感染期间都是非常重要的。然而，免疫系统长期暴露于I型IFN可破坏耐受性并引发自身免疫反应，最终导致自身免疫性疾病。最近对系统性红斑狼疮（SLE）患者的观察表明，这些个体具有内源性IFN-α诱导剂，导致持续的IFN-α产生，从而持续刺激免疫系统。这些IFN-α诱导剂由含有DNA或RNA的小免疫复合物（IC）组成，并作用于主要的IFN-α产生细胞，天然IFN-α产生细胞（NIPC），也称为浆细胞样树突细胞（PDC）。NIPC/PDC是先天性和适应性免疫应答中的关键细胞，但也可以直接或通过产生IFN-α在自身免疫中发挥关键作用。本文就NIPC/PDC的激活、调节、功能及其在自身免疫性疾病尤其是SLE中的作用作一综述。
The type I interferons (IFNs) have antiviral, cytostatic and prominent immunomodulatory effects, which all are of great importance during viral infections. However, prolonged exposure of the immune system to type I IFN can break tolerance and initiate an autoimmune reaction, eventually leading to autoimmune disease. Recent observations in patients with systemic lupus erythematosus (SLE) have revealed that such individuals have endogenous IFN-alpha inducers, causing an ongoing IFN-alpha production and consequently a continuous stimulation of the immune system. These IFN-alpha inducers consist of small immune complexes (IC) containing DNA or RNA and act on the principal IFN-alpha producing cell, the natural IFN-alpha producing cell (NIPC), also termed the plasmacytoid dendritic cell (PDC). The NIPC/PDC is a key cell in both the innate and adaptive immune response but can also, either directly or via produced IFN-alpha, have a pivotal role in autoimmunity. In this review we summarize recent data concerning NIPC/PDC, including their activation, regulation, function and possible role in autoimmune diseases, especially SLE.