Upper airway and diaphragm muscle responses to chemical stimulation and loading.
Upper airway and diaphragm muscle responses to chemical stimulation and loading.
复制标题
上呼吸道和膈肌对化学刺激和负荷的反应。
DOI：
10.1152/jappl.1982.53.5.1133
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Altose,MD
中科院分区：
文献类型：
--
作者：
Patrick,GB;Strohl,KP;Rubin,SB;Altose,MD
先前的研究表明，人类上呼吸道肌肉对化学呼吸驱动的变化的反应与横膈膜相似。为了验证这一假设，我们监测了9名健康受试者的鼻翼（AN），颏舌肌（GG）和膈肌（DI）的肌电图（EMG）活动，不仅对进行性等二氧化碳缺氧和高氧高碳酸血症，而且对有和没有外部吸气阻力（15 cmH 2 O × 1（-1）× s）的高氧高碳酸血症作出反应。DI、GG和AN响应于增加的化学驱动而线性增加，但一个受试者的AN和另一个受试者的GG对缺氧或高碳酸血症没有反应。响应吸气负荷，受试者减少通气（P <0.01），增加AN，GG和DI EMG活动（P <0.05）;然而，一名受试者没有显示出AN响应增加化学驱动或吸气负荷。我们的结论是，上呼吸道和膈肌的肌肉通常以平行的方式激活，因为呼吸受到缺氧，高碳酸血症和吸气阻力增加的刺激。
Previous studies suggest that upper airway muscles in humans respond to changes in chemical respiratory drive in a fashion similar to the diaphragm. To test this hypothesis, in nine seated healthy subjects we monitored electromyographic (EMG) activity from the alae nasi (AN), genioglossus (GG), and diaphragm (DI) not only in response to progressive isocapnic hypoxia and hyperoxic hypercapnia but also to hyperoxic hypercapnia with and without an external inspiratory resistance (15 cmH2O X 1(-1) X s). There were linear increases in DI, GG, and AN in response to increasing chemical drive, but the AN in one subject and the GG in another subject did not respond to hypoxia or hypercapnia. In response to an inspiratory load, subjects decreased ventilation (P less than 0.01) and increased AN, GG, and DI EMG activity (P less than 0.05); however, one subject did not show an AN response to either increased chemical drive or ventilatory loading. We conclude that muscles of the upper airway and the diaphragm are generally activated in a parallel fashion as respiration is stimulated by hypoxia, hypercapnia, and increased inspiratory resistance.