Astragalus membranaceus and Punica granatum alleviate infertility and kidney dysfunction induced by aging in male rats
Astragalus membranaceus and Punica granatum alleviate infertility and kidney dysfunction induced by aging in male rats
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DOI：
10.3906/biy-2001-5
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发表时间：
2020-01-01
影响因子：
2.2
通讯作者：
Salem, Ahmed M.
中科院分区：
文献类型：
--
作者：
Alshinnawy, Ameera S.;El-Sayed, Wael M.;Salem, Ahmed M.
随着年龄的增长，男性的生育能力和肾功能下降。因此，研究健康延长剂以克服衰老引起的不孕和肾功能障碍变得更加迫切。本研究旨在探讨黄芪端粒酶激活剂-65（Ta-65）和石榴补充剂的抗衰老作用。雄性Wistar大鼠40只，随机分为青年组、老年组、Ta-65组（500 mg/kg/d）和石榴组（250 mg/kg/d）。测定血清睾酮、FSH、LH和肾功能。进行精子分析以及睾丸组织学检查。衰老导致男性性激素失衡，导致精子异常，精子数量和活力减少。在老年大鼠中报告了血清肌酐、尿酸、钠和钾升高。Ta-65或石榴治疗有效地改善了男性生育力和肾功能正常老化引起的所有恶化。Ta-65和石榴通过重建激素平衡和睾丸结构来减轻衰老引起的男性不育，具有较强的抗衰老活性。它们还减轻了肾功能障碍。在比较Ta-65与石榴时，Ta-65对FSH、LH和精子异常的改善效果明显优于石榴。
By aging, male fertility and kidney function decline. Therefore, the investigation of health span-extending agents becomes more urgent to overcome aging-induced infertility and kidney dysfunction. The current research was undertaken to investigate the antiaging efficacy of Astragalus membranaceus telomerase activator-65 (Ta-65) and pomegranate supplements. Forty male Wistar rats were divided into young rats, aged rats, aged rats treated with Ta-65 (500mg/kg/day), and aged rats treated with pomegranate (250mg/kg/day). Testosterone, FSH, LH, and kidney functions were measured in serum. Sperm analysis as well as testicular histological examination was performed. Aging caused an imbalance in male sex hormones resulting in sperm abnormality and reductions in the sperm count and motility. Elevations in serum creatinine, uric acid, sodium, and potassium were reported in aged rats. Treatment with Ta-65 or pomegranate effectively ameliorated all the deteriorations induced by normal aging in male fertility and renal function. Ta-65 and pomegranate possessed strong antiaging activity by alleviating aging-induced male infertility through reestablishing the hormonal balance and testis architecture. They also alleviated the kidney dysfunction. On comparing Ta-65 with pomegranate, the improvement in FSH, LH, and sperm abnormalities caused by Ta-65 was much better than that caused by pomegranate.