Clinical manifestations of HIV-1 infection.
Clinical manifestations of HIV-1 infection.
复制标题
HIV-1感染的临床表现。
作者：
V. Verghese;T. Cherian;A. Cherian;P. Babu;T. John;C. Kirubakaran;P. Raghupathy
本研究描述了儿童医学院医院诊断的儿童中艾滋病毒/艾滋病的传播方式、临床表现和结果。数据取自1988年1月至2001年3月期间被诊断为HIV感染的88例儿童（50名男孩和38名女孩）的临床病例记录。结果表明，虽然HIV感染的主要传播途径是输血垂直传播，但仍然存在。还有证据表明，艾滋病毒感染导致疾病出现双峰进展。研究还发现，HIV感染的临床表现，如肝肿大、全身性淋巴结肿大、脾肿大、皮肤感染、反复腹泻和生长迟缓等，与发达国家其他研究中描述的相似，只是细菌感染比机会性感染更常见。研究结果表明，在缺乏容易负担得起的抗逆转录病毒疗法的情况下，及时诊断和治疗细菌感染以及预防卡氏肺孢子虫肺炎可能是延长艾滋病毒感染儿童生命和确保最佳健康的关键。
This study describes the mode of transmission clinical manifestations and outcome of HIV/AIDS among children diagnosed at the Children’s Medical College Hospital. Data were obtained from the 88 clinical case records of children (50 boys and 38 girls) diagnosed to have HIV infection from January 1988 to March 2001. Findings demonstrated that although the predominant route of transmission of HIV infection is vertical transmission via blood transfusion still takes place. There was also an evidence of a bimodal progression of disease due to HIV infection. The study also found that the clinical manifestations of HIV infection such as hepatomegaly generalized lymphadenopathy and splenomegaly skin infections recurrent diarrhea and failure to thrive were similar to those described in the other studies conducted in developed countries except that bacterial infections were more common than opportunistic infections. Based on the findings it is suggested that in the absence of easily affordable antiretroviral therapy prompt diagnosis and treatment of bacterial infections and Pneumocystis carinii pneumonia prophylaxis may be the keys to prolonging life and ensuring optimal health in children with HIV infections.