Magnetostrictive-Piezoelectric-Triggered Nanocatalytic Tumor Therapy
Magnetostrictive-Piezoelectric-Triggered Nanocatalytic Tumor Therapy
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DOI：
10.1021/acs.nanolett.1c01313
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发表时间：
2021-08-03
期刊：
影响因子：
10.8
通讯作者：
Shi, Jianlin
中科院分区：
文献类型：
--
作者：
Ge, Min;Xu, Deliang;Shi, Jianlin
Magnetic-based theranostics feature a high efficiency, excellent tissue penetration, and minimal damage to normal tissues, are noninvasive, and are widely used in the diagnosis and therapy of clinical diseases. Herein, a conceptually novel magnetostrictive-piezoelectric nanocatalytic medicine (MPE-NCM) for tumor therapy is proposed by initiating an intratumoral magneto-driven and piezoelectric-catalyzed reaction using core-shell structured CoFe2O4-BiFeO3 magnetostrictive-piezoelectric nanoparticles (CFO-BFO NPs) under an alternating magnetic field. The CFO-BFO NPs catalyze the generation of cytotoxic reactive oxygen species (ROS): superoxide radicals (center dot O-2(-)) and hydroxyl radicals (center dot OH). The simulation calculation demonstrates the highly controllable electric polarization, facilitating the above catalytic reactions under the magnetic stimulation. Both a detailed cell-level assessment and the tumor xenograft evaluation evidence the significant tumor eradication efficacy of MPE-NCM. This study proposes an original and novel magneto-responsive nanocatalytic modality for cancer therapy, which displays promising prospects for the future clinic translation owing to its excellent catalytic dynamic responsiveness, high therapeutic efficacy, and biosafety in vivo.
