Anterior cingulate cortex dysfunction in attention-deficit/hyperactivity disorder revealed by fMRI and the counting stroop
Anterior cingulate cortex dysfunction in attention-deficit/hyperactivity disorder revealed by fMRI and the counting stroop
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DOI：
10.1016/s0006-3223(99)00083-9
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发表时间：
1999-06-15
影响因子：
10.6
通讯作者：
Biederman, J
中科院分区：
文献类型：
--
作者：
Bush, G;Frazier, JA;Biederman, J
背景资料：前扣带认知区（ACcd）在注意加工中起着重要作用：1）调节刺激选择（即集中注意）和/或2）介导反应选择。我们假设，ACcd功能障碍可能因此有助于产生注意缺陷多动障碍（ADHD）的核心特征，即注意力不集中和冲动。ADHD受试者确实在Color Stroop（一种已知的注意力/认知干扰任务）上表现出表现缺陷。的ACCD。最近，一种专门用于功能性磁共振成像（fMRI）的Stroop变体Counting Stroop在健康成年人中产生ACcd激活。在本fMRI研究中，计数Stroop被用来检查ACCD在ADH.Methods的功能完整性：16个未服药的成年人从两组（8与ADHD和8匹配的对照组）进行计数Stroop在fMRI结果：虽然两组都表现出干扰效果，ADHD组，与对照组相比，未能激活ACCD在计数Stroop。直接比较显示，对照组中ACcd活性显著较高。ADHD受试者激活额纹状体-岛叶网络，表明ACcd功能减退不是由全球性的nehrronal反应性差引起的，结论：数据支持ADHD ACcd功能障碍的假设。
Background: The anterior cingulate cognitive division (ACcd) plays a central role in attentional processing by: 1) modulating stimulus selection (i.e,, focusing attention) and/or 2) mediating response selection. We hypothesized that ACcd dysfunction might therefore contribute to producing core features of attention-defcit/hyperactivity disorder (ADHD), namely inattention and impulsivity. ADHD subjects have indeed shown performance deficits on the Color Stroop, an attentional/cognitive interference task known to recuit. the ACcd. Recently, the Counting Stroop, a Stroop-variant specialized for functional magnetic resonance imaging (fMRI), produced ACcd activation in healthy adults. In the present fMRI study, the Counting Stroop was used to examine the functional integrity of the ACcd in ADHD.Methods: Sixteen unmedicated adults from two groups (8 with ADHD and 8 matched control subjects) performed the Counting Stroop during fMRIResults: While both groups showed an interference effect, the ADHD group, in contrast to control subjects, failed to activate the ACcd during the Counting Stroop. Direct comparisons showed ACcd activity was significantly higher in the control group. ADHD subjects did activate a frontostriatal-insular network indicating ACcd hypoactivity was not caused by globally poor nehrronal responsiveness,Conclusions: The data support a hypothesized dysfunction of the ACcd in ADHD.