The impact of peripheral arterial disease on health-related quality of life in the Peripheral Arterial Disease Awareness, Risk, and Treatment: New Resources For Survival (PARTNERS) Program
The impact of peripheral arterial disease on health-related quality of life in the Peripheral Arterial Disease Awareness, Risk, and Treatment: New Resources For Survival (PARTNERS) Program
复制标题
DOI：
10.1177/1358863x07084911
复制
发表时间：
2008-02-01
影响因子：
3.5
通讯作者：
Hirsch, Alan T.
中科院分区：
文献类型：
--
作者：
Regensteiner, Judith G.;Hiatt, William R.;Hirsch, Alan T.
本研究检验了PAD患者的健康相关生活质量（HRQoL）受损程度与其他类型心血管疾病（其他CVD）患者相似的假设，并评价了与HRQoL受损相关的PAD临床特征。这是一项在全国350个初级保健实践点进行的横断面研究，共有6，499名参与者。对照组没有PAD或其他CVD的临床或血流动力学证据; PAD组踝臂指数< 0.90或既往有PAD病史;其他CVD组有心脏或脑血管疾病的临床病史（但没有PAD），PAD-其他CVD联合组包括两种诊断。使用四种HRQoL问卷对个体进行评估，包括行走障碍问卷（WIQ）、医学结局研究SF-36（SF-36）、Cantril生活阶梯和PAD生活质量问卷。PAD患者的WIQ距离评分低于其他CVD组。PAD和其他CVD组的SF-36身体功能评分均显著低于参考组。WIQ显示PAD患者更受小腿疼痛的限制，而其他CVD患者更受胸痛、呼吸急促和心悸的限制。总之，在这项全国性研究中，首次直接比较了CVD与PAD的HRQoL负担，在诊所实践中对PAD的评价显示HRQoL负担与其他形式CVD患者一样大。
This study tested the hypothesis that patients with PAD have impaired health-related quality of life (HRQoL) to a degree similar to that of patients with other types of cardiovascular disease (other-CVD), and also evaluated the clinical features of PAD associated with impaired HRQoL. This was a cross-sectional study in 350 primary care practice sites nationwide with 6,499 participants. The reference group had no clinical or hemodynamic evidence of PAD or other-CVD; the PAD group had an ankle-brachial index < 0.90 or a prior history of PAD; the other-CVD group had a clinical history of cardiac or cerebral vascular disease ( but no PAD), and the combined PAD-other-CVD group included both diagnoses. Individuals were assessed using four HRQoL questionnaires including the Walking Impairment Questionnaire (WIQ), Medical Outcomes Study SF-36 ( SF-36), Cantril Ladder of Life and the PAD Quality of Life questionnaire. PAD patients had lower WIQ distance scores than the other-CVD group. Both the PAD and other-CVD groups had significantly lower SF-36 Physical Function scores compared with the reference group. The WIQ revealed that PAD patients were more limited by calf pain, whereas other-CVD patients were more limited by chest pain, shortness of breath and palpitations. In conclusion, in this nationwide study, one of the first to directly compare the HRQoL burden of CVD with that of PAD, the evaluation of PAD in office practice revealed a HRQoL burden as great in magnitude as in patients with other forms of CVD.