Synaptic mechanisms regulating the activation of a Ca2+-mediated plateau potential in developing relay cells of the LGN
Synaptic mechanisms regulating the activation of a Ca2+-mediated plateau potential in developing relay cells of the LGN
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DOI：
10.1152/jn.00715.1999
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发表时间：
2002-03-01
影响因子：
2.5
通讯作者：
Guido, W
中科院分区：
文献类型：
--
作者：
Lo, FS;Ziburkus, J;Guido, W
在离体大鼠脑干标本中，采用细胞内记录法，研究了外膝状体背侧核（LGN）发育中的中继神经元的突触反应。在新生大鼠中，强烈刺激视束（OT）诱发兴奋性突触后电位（EPSP），引起持续（300- 1，300 ms）、缓慢衰减（1 min），可被L型Ca 2+通道拮抗剂阻断。这些年龄相关的变化，Ca 2+信号可能有助于活性依赖性的细化retinogeniculate连接。
Using intracellular recordings in an isolated (in vitro) rat brain stem preparation, we examined the synaptic responses of developing relay neurons in the dorsal lateral geniculate nucleus (LGN). In newborn rats, strong stimulation of the optic tract (OT) evoked excitatory postsynaptic potentials (EPSPs) that gave rise to a sustained (300-1,300 ms), slow-decaying (1 min) that was blocked by L-type Ca2+ channel antagonists. These age-related changes in Ca2+ signaling may contribute to the activity-dependent refinement of retinogeniculate connections.