Hyperpolarized 3He Magnetic Resonance Imaging: Comparison with Four-dimensional X-ray Computed Tomography Imaging in Lung Cancer
Hyperpolarized 3He Magnetic Resonance Imaging: Comparison with Four-dimensional X-ray Computed Tomography Imaging in Lung Cancer
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DOI：
10.1016/j.acra.2012.08.007
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发表时间：
2012-12-01
影响因子：
4.8
通讯作者：
Parraga, Grace
中科院分区：
文献类型：
--
作者：
Mathew, Lindsay;Wheatley, Andrew;Parraga, Grace
基本原理和目标：使用四维X射线计算机断层扫描（4DCT）成像和超极化He-3磁共振成像（MRI）的肺功能成像提供了肺癌患者的局部肺功能估计，其中肺功能测量通常由肿瘤负荷主导。本研究的目的是评估4DCT和超极化3 He MRI ventilation maps.Materials and Methods之间的定量空间关系：11例肺癌患者提供书面知情同意书，4DCT成像和MRI在11 +/- 14天内进行。超极化He-3 MRI是从1 L超极化He-3的功能性残余容量吸入后屏气获得的，而4DCT成像是在室内空气的单次潮气呼吸中获得的。对于超极化3 He MRI，使用半自动分割生成通气量百分比;对于4DCT成像，使用吸气和呼气阶段相同组织元素之间的对应关系生成肺功能图，以生成通气量百分比。（He-3 MRI：同侧1.9 +/- 0.5 L，对侧2.3 +/- 0.7 L; 4DCT成像：1.2 +/- 0.3 L同侧，1.3 +/- 0.4 L对侧），超极化He-3 MRI之间的通气量百分比无显著差异（同侧72 +/- 11%，对侧79 +/- 12%）和4DCT成像（同侧74 +/- 3%，对侧75 +/- 4%）。使用Dice相似系数指数评价4DCT和He-3 MRI通气之间的空间对应性（同侧，86 +/- 12%;对侧，88 +/- 12%）。尽管在图像采集呼吸操作方面存在相当大的差异，但在超极化He-3 MRI和4DCT成像上观察到通气图具有良好的空间和显著的定量一致性，这表明在这一小组肺癌患者中，具有良好肺功能的肺区域在模式之间是相似的。
Rationale and Objectives: Pulmonary functional imaging using four-dimensional x-ray computed tomographic (4DCT) imaging and hyperpolarized He-3 magnetic resonance imaging (MRI) provides regional lung function estimates in patients with lung cancer in whom pulmonary function measurements are typically dominated by tumor burden. The aim of this study was to evaluate the quantitative spatial relationship between 4DCT and hyperpolarized 3He MRI ventilation maps.Materials and Methods: Eleven patients with lung cancer provided written informed consent to 4DCT imaging and MRI performed within 11 +/- 14 days. Hyperpolarized He-3 MRI was acquired in breath-hold after inhalation from functional residual capacity of 1 L hyperpolarized He-3, whereas 4DCT imaging was acquired over a single tidal breath of room air. For hyperpolarized 3He MRI, the percentage ventilated volume was generated using semiautomated segmentation; for 4DCT imaging, pulmonary function maps were generated using the correspondence between identical tissue elements at inspiratory and expiratory phases to generate percentage ventilated volume.Results: After accounting for differences in image acquisition lung volumes (He-3 MRI: 1.9 +/- 0.5 L ipsilateral, 2.3 +/- 0.7 L contralateral; 4DCT imaging: 1.2 +/- 0.3 L ipsilateral, 1.3 +/- 0.4 L contralateral), there was no significant difference in percentage ventilated volume between hyperpolarized He-3 MRI (72 +/- 11% ipsilateral, 79 +/- 12% contralateral) and 4DCT imaging (74 +/- 3% ipsilateral, 75 +/- 4% contralateral). Spatial correspondence between 4DCT and He-3 MRI ventilation was evaluated using the Dice similarity coefficient index (ipsilateral, 86 +/- 12%; contralateral, 88 +/- 12%).Conclusions: Despite rather large differences in image acquisition breathing maneuvers, good spatial and significant quantitative agreement was observed for ventilation maps on hyperpolarized He-3 MRI and 4DCT imaging, suggesting that pulmonary regions with good lung function are similar between modalities in this small group of patients with lung cancer.