Association between periodontal pockets and elevated cholesterol and low density lipoprotein cholesterol levels
Association between periodontal pockets and elevated cholesterol and low density lipoprotein cholesterol levels
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DOI：
10.1902/jop.2002.73.5.494
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发表时间：
2002-05-01
影响因子：
4.3
通讯作者：
Heft, M
中科院分区：
文献类型：
--
作者：
Katz, J;Flugelman, MY;Heft, M
背景资料：牙周炎与心血管疾病发病率和死亡率的增加有关;然而，这种联系的性质尚不清楚。有一个基本原理表明，牙周袋的存在，可以窝藏病原微生物，并引起宿主反应，可能会引起全身效应。这项研究的假设是，牙周袋可能与血脂水平升高，动脉粥样硬化diseases.Methods的一个已知的危险因素：牙周健康的10,590名以色列军人的男性和女性进行了评估，使用社区牙周病治疗需求指数（CPITN）。血脂和牙周疾病和CPITN指数的关系进行了测试，控制相关的因素，胆固醇水平升高，包括高体重指数（BMI），年龄，舒张压，和smoking.Results：牙周袋的存在与高胆固醇和低密度脂蛋白（LDL）胆固醇血液水平的男性。没有显着的关联被发现在women.Conclusions：在这个大的队列研究中，牙周袋的存在，CPITN测量与总胆固醇和LDL-胆固醇呈正相关。这项研究的结果支持了牙周病患者心血管死亡率增加的报告。
Background: Periodontitis is associated with increased prevalence of cardiovascular morbidity and mortality; however, the nature of this association is unclear. There is a rationale that indicates that the presence of periodontal pockets which can harbor pathogenic microorganisms and evoke a host response could elicit a systemic effect. The hypothesis of this study is that periodontal pockets may be associated with elevated blood lipid levels, a known risk factor for atherosclerotic disease.Methods: The periodontal health of 10,590 Israeli military service men and women was assessed using the Community Periodontal Index of Treatment Needs (CPITN). The relationship of blood lipids and periodontal disease and CPITN index was tested, controlling for factors that are related to elevated cholesterol levels, including high body mass index (BMI), age, diastolic blood pressure, and smoking.Results: The presence of periodontal pockets was positively associated with higher cholesterol and low density lipoprotein (LDL) cholesterol blood levels in men. No significant association was found in women.Conclusions: In this large cohort study, the presence of periodontal pockets as measured by CPITN was positively associated with total cholesterol and LDL-cholesterol. The findings of the study support the reports linking increased prevalence of cardiovascular mortality among patients with periodontal disease.