Potassium channels of adult locust (Schistocerca gregaria) muscle
Potassium channels of adult locust (Schistocerca gregaria) muscle
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成年蝗虫（Schistocerca gregaria）肌肉的钾通道
DOI：
10.1007/s004240050175
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
P. Usherwood
中科院分区：
文献类型：
--
作者：
E. Gorczynska;P. Huddie;B. Miller;I. Mellor;H. Vais;R. Ramsey;P. Usherwood
在成年蝗虫（Schistocerca gregaria）后胸胫骨伸肌纤维质膜斑块中发现了两种类型的 K+ 通道。一个通道的最大电导为 170 pS、快速开闭动力学以及线性电流/电压关系。在由内而外的斑块中，它被“内部应用”的 Ca2+ 激活，但水平出乎意料地低（10−10 和 10−9M 之间）。另一个通道的最大电导为 35 pS，开闭动力学较慢，并且不被 Ca2+ 激活。在细胞贴附的贴片中，在对称盐水中测量的通道电导在超极化时大约是去极化时的三倍。这种向内的整流被证明是由于细胞内Mg2+的阻断所致。对于两个通道，开放概率 (Po) 和平均开放时间在去极化期间增加，在超极化期间减少，导致净电流（In，单通道电流和 Po 的乘积）方面的向外整流。对于两个通道，K+ 电导比 Na+ 电导大 10 倍。内部施加的四乙基铵或四甲基铵离子阻断了两个通道。
Two types of K+ channels have been identified in patches of plasma membrane of metathoracic extensor tibiae muscle fibres of adult locust, Schistocerca gregaria. One channel had a maximum conductance of 170 pS, fast open-closed kinetics, and a linear current/ voltage relationship. In inside-out patches it was activated by “internally applied” Ca2+, but at unexpectedly low levels (between 10−10 and 10−9M). The other channel had a maximum conductance of 35 pS, slower open-closed kinetics, and was not activated by Ca2+. In cell-attached patches, its channel conductance measured in symmetrical salines was about three times greater for hyperpolarisations than for depolarisations. This inward rectification was proved to be due to block by intracellular Mg2+. For both channels, open probability (Po) and mean open time increased during depolarisations and decreased during hyperpolarisations, resulting in outward rectifications in terms of net current (In, product of the single-channel current and Po). For both channels, the K+ conductance was 10 times greater than that for Na+. Internally applied tetraethyl-ammonium or tetramethylammonium ions blocked both channels.
DOI：
--
发表时间：
1993
期刊：
Mineral and electrolyte metabolism
影响因子：
--
作者：
Kelepouris,E;Kasama,R;Agus,ZS
通讯作者：
Agus,ZS
含多胺毒素选择性拮抗天然和克隆红藻氨酸和 NMDA 受体。
DOI：
--
发表时间：
1993
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Brackley,PT;Bell,DR;Choi,SK;Nakanishi,K;Usherwood,PN
通讯作者：
Usherwood,PN
通过电子自旋共振进行横向扩散的动态成像以及模型膜中旋转动力学的研究。
影响因子：
3.4
作者：
Shin,YK;Freed,JH
通讯作者：
Freed,JH