The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
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DOI：
10.1097/00006982-199414030-00022
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发表时间：
1994-06
影响因子：
1.6
通讯作者：
Douglas Rogers
中科院分区：
文献类型：
--
作者：
Douglas Rogers
从1983年到，726例病程1~5年、无糖尿病视网膜病变征象的胰岛素依赖型糖尿病患者进入糖尿病控制及并发症试验。患者年龄在13岁至39岁之间，18%的患者年龄在13岁至18岁之间。患者被随机分为常规治疗组或强化治疗组。常规治疗的患者每天注射一到两次混合的常规和中效胰岛素。接受强化治疗的患者每天至少注射三次胰岛素或使用胰岛素泵。接受强化治疗的患者每天至少检查四次血糖。然后，可以根据血糖水平和预期的饮食摄入量和锻炼来调整每个胰岛素剂量。强化治疗的目标
Sumrnary: From 1983 through 1989, 726 patients with insulin-dependent diabetes mellitus (IDDM) of 1 to 5 years’ duration and with no sign of diabetic retinopathy were enrolled into the Diabetes Control and Complications Trial. The patients were between 13 and 39 years old; 18% were between 13 and 18 years old. The patients were randomized into either a conventional treatment group or an intensive treatment group. Conventionally treated patients took one or two injections of mixed regularand intermediate-acting insulin daily. Intensively treated patients took at least three injections of insulin daily or used an insulin pump. Intensively treated patients also checked their blood glucose at least four times daily. Each insulin dose could then be adjusted, based on the blood glucose level and the anticipated dietary intake and exercise. The goal of intensive therapy