Mesenchymal stem cell-educated macrophages.
Mesenchymal stem cell-educated macrophages.
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DOI：
10.1186/2047-1440-1-12
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发表时间：
2012-09-28
期刊：
影响因子：
--
通讯作者：
Hoogduijn MJ
中科院分区：
文献类型：
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作者：
Eggenhofer E;Hoogduijn MJ
间充质干细胞（MSC）通过多种机制介导其免疫抑制作用。这些机制之一涉及诱导具有免疫调节能力的巨噬细胞。当MSC用作细胞治疗产品时，可以利用MSC的这种作用。此外，MSC驻留在组织中，它们可以局部靶向浸润的巨噬细胞以适应更多的调节特性。本文讨论了MSC与巨噬细胞之间的相互作用、MSC诱导的巨噬细胞的诱导、这些细胞如何定位在其他免疫调节细胞之间以及它们如何在临床中使用。
Mesenchymal stem cells (MSC) mediate their immunosuppressive effects via a variety of mechanisms. One of these mechanisms involves the induction of macrophages with immunomodulatory capacities. This effect of MSC may be exploited when MSC are used as a cell therapeutic product. Furthermore, MSC are resident in tissues where they may locally target infiltrating macrophages to adapt more regulatory properties. The present review discusses the interaction between MSC and macrophages, the induction of MSC-educated macrophages, how these cells position between other immune regulatory cells, and how they may be used in the clinic.