Collagen coating promotes biocompatibility of semiconductor nanoparticles in stratified LBL films
Collagen coating promotes biocompatibility of semiconductor nanoparticles in stratified LBL films
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DOI：
10.1021/nl0255045
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发表时间：
2003-09-01
期刊：
影响因子：
10.8
通讯作者：
Kotov, NA
中科院分区：
文献类型：
--
作者：
Sinani, VA;Koktysh, DS;Kotov, NA
由半导体纳米颗粒（NP）制备的纳米结构薄膜在生物医学应用中具有极大的兴趣，但是基于重金属的NP材料可以具有细胞毒性。在这项工作中，半导体纳米颗粒的制备遵循逐层（LBL）组装的协议，这解决了这个问题。将胶原/聚丙烯酸双层膜添加到CdTe/聚阳离子LBL膜中以制备多孔胶原双层膜。这种分层的多层系统显示出成功的细胞附着和存活，而天然NP膜具有强烈的细胞毒性。
Nanostructured thin films fabricated from semiconductor nanoparticles (NPs) are of great interest for biomedical applications, but NP materials based on heavy metals can be cytotoxic. In this work, the preparation of semiconductor NPs followed the protocol of layer-by-layer (LBL) assembly, which alleviates this problem. Collagen/poly(acrylic acid) bilayers were added to CdTe/polycation LBL films to produce porous collagen bilayers. Such stratified multilayer systems showed successful cell attachment and survival while native NP films were strongly cytotoxic.