Structures of chromatin modulators in complex with nucleosome
Structures of chromatin modulators in complex with nucleosome
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与核小体复合的染色质调节剂的结构
DOI：
10.1016/j.cbpa.2021.02.018
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Ke Liu
中科院分区：
文献类型：
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作者：
Jinrong Min;Ke Liu
染色质结构由许多不同的调节剂动态调节，这些调节剂在翻译后修饰组蛋白，用组蛋白变体取代规范的组蛋白，并解开核小体DNA，从而调节核小体DNA的可及性，促进下游DNA模板核过程。为了了解这些调节剂是如何改变染色质结构的，确定染色质调节剂与核小体形成的复合体的三维结构是至关重要的。本文综述了核小体复合体中一些染色质调节剂的最新结构研究进展，包括组蛋白去甲基酶LSD1/2、一些先驱转录因子以及含有PWWP结构域的蛋白LEDGF。
The chromatin structure is dynamically regulated by many different modulators that post-translationally modify histones, replace canonical histones with histone variants, and unwind nucleosomal DNA, thereby modulating the accessibility of nucleosomal DNA and facilitating downstream DNA-templated nuclear processes. To understand how these modulators change the chromatin structure, it is essential to determine the 3D structures of chromatin modulators in complex with nucleosome. Here, we review the very recent progress in structural studies of some selected chromatin modulators in complex with nucleosome, including those of histone demethylases LSD1/2, some pioneer transcription factors, and the PWWP domain–containing protein LEDGF.