A thermo-responsive alginate nanogel platform co-loaded with gold nanoparticles and cisplatin for combined cancer chemo-photothermal therapy
A thermo-responsive alginate nanogel platform co-loaded with gold nanoparticles and cisplatin for combined cancer chemo-photothermal therapy
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DOI：
10.1016/j.phrs.2019.01.005
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发表时间：
2019-05-01
影响因子：
9.3
通讯作者：
Shakeri-Zadeh, Ali
中科院分区：
文献类型：
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作者：
Mirrahimi, Mehri;Abed, Ziaeddin;Shakeri-Zadeh, Ali
目前，癌症研究的兴趣正在从个体治疗转向组合治疗。在这方面的贡献，一种新的多功能纳米平台，包括海藻酸钠纳米凝胶共负载顺铂和金纳米粒子（AuNPs）已首次开发出联合收割机光热治疗和化疗。针对CT 26结直肠肿瘤模型测试所制备的纳米复合物的抗肿瘤功效。纳米复合物显示出比游离顺铂更好的化疗效果，并引起显著更高的肿瘤抑制率。体内温度测量结果表明，用纳米复合物处理的肿瘤在532 nm激光照射下具有更快的温度上升速率，并且由于AuNPs的光学吸收特性而接收到显著更高的热剂量。使用纳米复合物的化学光热疗法的联合作用显著抑制肿瘤生长高达对照的95%，并显著延长动物存活率。此外，通过[F-18]FDG（2-脱氧-2-[F-18]氟-D-葡萄糖）-正电子发射断层扫描（PET）成像定量肿瘤代谢，并显示纳米复合物和激光照射的组合具有根除微观残留肿瘤以预防癌症复发的潜力。因此，纳米复合物可以提供有效的抗癌功效，从而可以将热和药物有效地递送到肿瘤，并且同时可以潜在地减少由于单独应用化疗和热疗法而引起的高剂量相关副作用。
The current interest in cancer research is being shifted from individual therapy to combinatorial therapy. In this contribution, a novel multifunctional nanoplatform comprising alginate nanogel co-loaded with cisplatin and gold nanoparticles (AuNPs) has been firstly developed to combine photothermal therapy and chemotherapy. The antitumor efficacy of the as-prepared nanocomplex was tested against CT26 colorectal tumor model. The nanocomplex showed an improved chemotherapy efficacy than free cisplatin and caused a significantly higher tumor inhibition rate. The in vivo thermometry results indicated that the tumors treated with the nanocomplex had faster temperature rise rate under 532 nm laser irradiation and received dramatically higher thermal doses due to optical absorption properties of AuNPs. The combined action of chemo-photothermal therapy using the nanocomplex dramatically suppressed tumor growth up to 95% of control and markedly prolonged the animal survival rate. Moreover, tumor metabolism was quantified by [F-18]FDG (2-deoxy-2-[F-18] fluoro-D-glucose)-positron emission tomography (PET) imaging and revealed that the combination of the nanocomplex and laser irradiation have the potential to eradicate microscopic residual tumor to prevent cancer relapse. Therefore, the nanocomplex can afford a potent anticancer efficacy whereby heat and drug can be effectively deliver to the tumor, and at the same time the high dose-associated side effects due to the separate application of chemotherapy and thermal therapy could be potentially reduced.