Maternal obesity in the rat programs male offspring exploratory, learning and motivation behavior: prevention by dietary intervention pre-gestation or in gestation
Maternal obesity in the rat programs male offspring exploratory, learning and motivation behavior: prevention by dietary intervention pre-gestation or in gestation
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DOI：
10.1016/j.ijdevneu.2011.12.012
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发表时间：
2012-04-01
影响因子：
1.8
通讯作者：
Zambrano, E.
中科院分区：
文献类型：
--
作者：
Rodriguez, J. S.;Rodriguez-Gonzalez, G. L.;Zambrano, E.
我们研究了母亲高脂肪饮食（HFD，25%的热量来自于怀孕前和怀孕期间和哺乳期的脂肪）和饮食干预（将母亲从HFD切换到对照饮食）在不同围受孕期对雄性后代焦虑相关行为、探索、学习和动机的影响。从出生后第21天断奶开始，在研究中生产成为母亲的女性受试者接受对照饮食（CTR - 5%的热量来自脂肪），HFD通过怀孕和哺乳期（MO），PND 21-90期间的HFD，随后为CTR饮食（妊娠前（PG）干预）或从PND 21至120的HFD，随后CTR饮食（妊娠和哺乳（G）干预），并在PND 120饲养。在妊娠19天时，MO组母体血清皮质酮升高，PG组和G组母体血清皮质酮部分恢复，且水平处于中等水平。在后代中，在高架十字迷宫测试中未发现影响。在旷场试验中，MO和G的后代表现出增加区域条目，显示较少的趋触性; PG后代表现出部分恢复这种行为。在最初的操作性条件反射MO。PG和G的后代表现出减少的方法行为与随后的学习障碍，在收购FR-1和FR-5操作条件的蔗糖强化。动机在累进比率测试中增加MO后代; PG和G干预恢复了这种行为。我们的结论是，饮食干预可以扭转负面影响的母亲HFD和后代的结果可能是由于母体皮质酮升高。(C)2012 ISDN。由爱思唯尔有限公司出版。保留所有权利。
We studied the effects of maternal high fat diet (HFD, 25% calories from fat administered before and during pregnancy and lactation) and dietary intervention (switching dams from HFD to control diet) at different periconceptional periods on male offspring anxiety related behavior, exploration, learning, and motivation. From weaning at postnatal day (PND) 21, female subjects produced to be the mothers in the study received either control diet (CTR - 5% calories from fat), HFD through pregnancy and lactation (MO), HFD during PNDs 21-90 followed by CTR diet (pre-gestation (PG) intervention) or HFD from PND 21 to 120 followed by CTR diet (gestation and lactation (G) intervention) and bred at PND 120. At 19 days of gestation maternal serum corticosterone was increased in MO and the PG and G dams showed partial recovery with intermediate levels. In offspring, no effects were found in the elevated plus maze test. In the open field test, MO and G offspring showed increase zone entries, displaying less thigmotaxis; PG offspring showed partial recuperation of this behavior. During initial operant conditioning MO. PG and G offspring displayed decreased approach behavior with subsequent learning impairment during the acquisition of FR-1 and FR-5 operant conditioning for sucrose reinforcement. Motivation during the progressive ratio test increased in MO offspring; PG and G intervention recuperated this behavior. We conclude that dietary intervention can reverse negative effects of maternal HFD and offspring outcomes are potentially due to elevated maternal corticosterone. (C) 2012 ISDN. Published by Elsevier Ltd. All rights reserved.