SYNTHESIS IN SOLUTION OF PEPTOIDS USING FMOC-PROTECTED N-SUBSTITUTED GLYCINES
SYNTHESIS IN SOLUTION OF PEPTOIDS USING FMOC-PROTECTED N-SUBSTITUTED GLYCINES
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DOI：
10.1016/00404-0399(50)1382r
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发表时间：
1995-09-18
影响因子：
1.8
通讯作者：
LISKAMP, RMJ
中科院分区：
文献类型：
--
作者：
KRUIJTZER, JAW;LISKAMP, RMJ
介绍了以溴乙酸乙酯为起始原料，方便地合成了fmoc保护的n -取代甘氨酸衍生物。作为使用这些构建块制备类肽的一个例子，显示了P物质（SP）的c端五反肽的合成。
A convenient synthesis of Fmoc-protected N-substituted glycine derivatives starting from ethyl bromoacetate is described. As an illustration of the use of these building blocks Tor the preparation of peptoids, the synthesis of the C-terminal penta retropeptoid of Substance P (SP) is shown.