AEROSOL SOLVENT-EXTRACTION SYSTEM - A NEW MICROPARTICLE PRODUCTION TECHNIQUE
AEROSOL SOLVENT-EXTRACTION SYSTEM - A NEW MICROPARTICLE PRODUCTION TECHNIQUE
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DOI：
10.1016/0378-5173(93)90131-x
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发表时间：
1993-08-15
影响因子：
5.8
通讯作者：
WASSMUS, W
中科院分区：
文献类型：
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作者：
BLEICH, J;MULLER, BW;WASSMUS, W
气溶胶溶剂萃取系统(ASES)利用超临界气体的萃取特性来生产微粒。超临界气体萃取在食品工业和分析化学中经常使用。在ASES过程中，药物和聚合物被溶解或分散在有机溶剂中，该有机溶剂被喷射到超临界气相(例如二氧化碳)中。有机溶剂在超临界气相中溶解，被提取后形成固体微粒。研究了聚乳酸、丙交酯/乙交酯比例为50：50和75：25的聚乳酸-乙交酯共聚物、L-丙交酯和聚β-羟基丁酸等不同的生物可降解聚合物在ASES中的适用性。提取聚合物PDLA和PLGA(75：25)。使用PLGA(50：50)进行部分萃取，并在收集容器中形成聚合物膜。用PIA和PHB法制备了微球。颗粒呈球形，粒径范围(X50%)为1-10微米。
The aerosol solvent extraction system (ASES) utilises the extraction properties of supercritical gases for the production of microparticles. Extraction with supercritical gases is frequently used in the food industry and in analytical chemistry. In the ASES process drug and polymer are dissolved or dispersed in an organic solvent which is sprayed into a supercritical gas phase (e.g., carbon dioxide). The organic solvent is soluble in the supercritical gas phase and is extracted resulting in the formation of solid microparticles. Different biodegradable polymers, poly(DL-lactide) (PDLA), poly(DL-lactide-co-glycolide) (PGLA) with lactide/glycolide ratios (50: 50) and (75: 25), poly(L-lactide) (PLA) and poly(beta-hydroxybutyric acid) (PHB) were tested for their suitability in ASES. The polymers PDLA and PLGA (75:25) were extracted. The use of PLGA (50:50) led to partial extraction and a polymer film in the collecting vessel. Microparticles were obtained using PIA and PHB. The particles were spherical and the particle size range (X50%) was 1-10 mum.