BEHAVIORAL-EFFECTS OF DOPAMINE APPLIED INTRACEREBRALLY TO AREAS OF MESOLIMBIC SYSTEM
BEHAVIORAL-EFFECTS OF DOPAMINE APPLIED INTRACEREBRALLY TO AREAS OF MESOLIMBIC SYSTEM
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DOI：
10.1016/0014-2999(75)90326-x
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发表时间：
1975-01-01
影响因子：
5
通讯作者：
NAYLOR, RJ
中科院分区：
文献类型：
--
作者：
COSTALL, B;NAYLOR, RJ
采用脑内注射技术，将多巴胺直接注入中脑边缘系统的含多巴胺区域，即隔隔核、嗅结节和中央杏仁核。向双侧延髓隔核注射200 μg多巴胺可引起刻板的嗅行为和多动，但向嗅结节注射类似的多巴胺后，只出现周期性的多动，向杏仁中央核注射多巴胺后，没有观察到行为的改变。脑内多巴胺作用增强，1-50 μg多巴胺可引起一致性刻板嗅闻，并呈剂量依赖性地向隔核或嗅结节内注射。从延髓隔核开始的作用最为显著。此外，嗅结节内注射50-100 μg多巴胺可引起周期性的咬行为。在注射到延髓隔核后没有观察到咬，并且即使在存在甲酰胺的情况下，将多巴胺注射到杏仁中央核也未能引起运动行为的任何变化。
The intracerebral injection technique was used to apply dopamine directly into dopamine-containing areas of the mesolimbic system, the nucleus accumbens septi, tuberculum olfactorium and nucleus amygdaloideus centralis. 200 μg dopamine injected bilaterally into the nucleus accumbens septi caused a stereotyped sniffing behaviour and hyperactivity but only a periodic hyperactivity developed after similar injections into the tuberculum olfactorium and no change in behaviour was observed following injections into the nucleus amygdaloideus centralis. After pretreatment with nialamide, the effects of intracerebral dopamine were enhanced, doses of 1–50 μg dopamine causing consistent stereotyped sniffing and a dose-dependent hyperactivity on injection into the nucleus accumbens septi or tuberculum olfactorium. The effects initiated from the nucleus accumbens septi were most marked. In addition, 50–100 μg dopamine injected into the tuberculum olfactorium caused a periodic biting behaviour. Biting was not observed after injections into the nucleus accumbens septi and, even in the presence of nialamide, injections of dopamine into the nucleus amygdaloideus centralis failed to cause any change in motor behaviour.