Age-related and Genetic Modulation of Frontal Cortex Efficiency
Age-related and Genetic Modulation of Frontal Cortex Efficiency
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DOI：
10.1162/jocn_a_00521
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发表时间：
2014-04-01
影响因子：
3.2
通讯作者：
Nilsson, Lars-Goran
中科院分区：
文献类型：
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作者：
Nyberg, Lars;Andersson, Micael;Nilsson, Lars-Goran
背外侧PFC(DLPFC)是工作记忆的关键区域。有人提出，DLPFC是根据任务需求动态招募的。根据这一观点，低要求任务的高DLPFC招募和较高任务要求的DLPFC弱上调反映了低效率。在这里，在一个具有代表性的大样本(n=287)中，研究了工作记忆维持和操作过程中的fMRI BOLD信号与衰老和儿茶酚-O-甲基转移酶(COMT)Val(158)Met状态的关系。效率假说预测，与年轻人和COMT Met携带者相比，老年人和COMT Val携带者在操作过程中的DLPFC反应较弱，而在维护期间的反应较强。与假设一致的是，年轻人和MET携带者在操作过程中表现出最大的DLPFC大胆反应，而老年人和Val携带者在要求较低的维护条件下表现出较高的DLPFC反应。观察到的倒置关系支持多巴胺和DLPFC效率之间的联系。
The dorsolateral pFC (DLPFC) is a key region for working memory. It has been proposed that the DLPFC is dynamically recruited depending on task demands. By this view, high DLPFC recruitment for low-demanding tasks along with weak DLPFC upregulation at higher task demands reflects low efficiency. Here, the fMRI BOLD signal during working memory maintenance and manipulation was examined in relation to aging and catechol-O-methyltransferase (COMT) Val(158)Met status in a large representative sample (n = 287). The efficiency hypothesis predicts a weaker DLPFC response during manipulation, along with a stronger response during maintenance for older adults and COMT Val carriers compared with younger adults and COMT Met carriers. Consistent with the hypothesis, younger adults and met carriers showed maximal DLPFC BOLD response during manipulation, whereas older adults and val carriers displayed elevated DLPFC responses during the less demanding maintenance condition. The observed inverted relations support a link between dopamine and DLPFC efficiency.