Microenvironmental targeting of Wnt/β-catenin signals for hematopoietic stem cell regulation
Microenvironmental targeting of Wnt/β-catenin signals for hematopoietic stem cell regulation
复制标题
DOI：
10.1517/14712598.2010.504705
复制
发表时间：
2010-08
影响因子：
4.6
通讯作者：
I. Oh
中科院分区：
文献类型：
--
作者：
I. Oh
该领域的重要性：微环境已成为干细胞生态位中造血干细胞（hsc）调控的关键因素。最近的研究表明，Wnt/β-catenin信号明显参与干细胞生态位，这提高了造血微环境是干细胞治疗潜在靶点的可能性。本文综述了不同研究模型中Wnt/β-catenin信号对HSC活性的生物学影响，并对差异的潜在原因进行了讨论。总结了Wnt/β-catenin信号微环境靶向的证据和验证这一概念的研究。读者将获得什么：我们表明，Wnt/β-catenin对造血干细胞的不同影响可以根据其在造血微环境中的激活目标而引起。我们发现骨髓再生过程中Wnt/β-catenin信号的基质靶向性以及与缺口信号的交互作用增强了造血干细胞的自我更新。要点：基质介导的Wnt/β-catenin效应的鉴定现在允许整合先前报道的发现的差异，并表明基质靶向Wnt/β-catenin信号可以作为激活干细胞生态位的潜在治疗策略，以实现造血干细胞的有效再生。
Importance of the field: Microenvironment has emerged as crucial element in the regulation of hematopoietic stem cells (HSCs) in the stem cell niche. Recent studies have demonstrated that Wnt/β-catenin signals are clearly involved in the stem cell niche, raising the possibility that the hematopoietic microenvironment is a potential target for stem cell therapy. Areas covered in this review: In this review, the biological outcomes of Wnt/β-catenin signals on HSC activity are summarized in various study models and potential reasons for discrepancies are discussed. Evidence for the microenvironmental targeting of Wnt/β-catenin signals and studies that verify this concept is summarized. What the reader will gain: We show that distinct effects of Wnt/β-catenin on HSCs can be caused depending on their target of activation in the hematopoietic microenvironment. We show stromal targeting of Wnt/β-catenin signals and cross-talk with notch signals in the niche during bone marrow regeneration enhancing the self-renewal of HSCs. Take home message: The identification of stroma-mediated Wnt/β-catenin effects now allows the integration of discrepancies in previously reported findings and suggests that the stromal targeting of wnt/β-catenin signals could serve as a potential therapeutic strategy for activating a stem cell niche for the efficient regeneration of HSCs.