Layers of structure and function in protein aggregation.
Layers of structure and function in protein aggregation.
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DOI：
10.1038/nchembio.1818
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发表时间：
2015-06
影响因子：
14.8
通讯作者：
Motomasa Tanaka;Yusuke Komi
中科院分区：
文献类型：
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作者：
Motomasa Tanaka;Yusuke Komi
蛋白质聚集是许多神经退行性疾病的中心标志，但聚集体结构多样性与所得细胞毒性和表型多样性的关系仍然不清楚。通过化学生物学方法，如合理设计的蛋白质修饰和化学探针，在理解蛋白质聚集机制及其生理后果方面取得了最新进展，为脑疾病的治疗策略提供了重要的机制见解和前景。
Protein aggregation is a central hallmark of many neurodegenerative disorders, but the relationship of aggregate structural diversity to the resultant cellular cytotoxicity and phenotypic diversity has remained obscure. Recent advances in understanding the mechanisms of protein aggregation and their physiological consequences have been achieved through chemical biology approaches, such as rationally designed protein modifications and chemical probes, providing crucial mechanistic insights and promise for therapeutic strategies for brain disorders.