Serum zinc and copper concentrations in relation to spontaneous abortion in cows: implications for human fetal loss.
Serum zinc and copper concentrations in relation to spontaneous abortion in cows: implications for human fetal loss.
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DOI：
10.1530/jrf.0.1020253
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发表时间：
1994-09
期刊：
影响因子：
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通讯作者：
T. Graham;M. Thurmond;M. Gershwin;J. Picanso;J. Garvey;C. L. Keen
中科院分区：
文献类型：
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作者：
T. Graham;M. Thurmond;M. Gershwin;J. Picanso;J. Garvey;C. L. Keen
本研究的目的是调查 570 头奶牛的膳食锌状况以及血清锌和铜浓度对胎儿流产风险的影响。三个牛群没有接受任何补充剂（牛群 1、3、4），而牛群 2 中的奶牛在第 1 周接受 7 克锌补充剂（n = 118），即蛋氨酸锌，或含有蛋氨酸的对照饮食（n = 128）。在整个妊娠期间每月测定一次血清锌、铜和金属硫蛋白浓度。使用逻辑回归和生存分析来检查胎儿流产风险与血清锌、铜、铜：锌或金属硫蛋白浓度、补充剂水平和母亲受孕年龄之间的关联。当血清锌降低且铜浓度升高时，胎儿流产的风险增加（P < 0.0001；相对风险 = 10.28，95% 置信区间 = 4.69、22.5）。锌浓度下降10 mumol l-1 和铜浓度增加5 mumol l-1 的归因风险为90.27%。与补充锌蛋氨酸的奶牛相比，补充蛋氨酸的奶牛流产的风险更高（单尾 P = 0.0375；相对风险 = 2.98）。牛群 1、3 和 4 中的奶牛流产风险高于牛群 2 中补充锌蛋氨酸的奶牛（相对风险 = 26.27，95% 置信区间 = 2.31, 299.38；相对风险 = 40.87，95% 置信区间 = 3.50, 458.43；相对风险 = 41.53， 95% 置信区间分别 = 3.77、457.02）。我们的结果表明炎症和锌营养可能在奶牛流产中发挥重要作用。
The purpose of this study was to investigate the effect of the status of dietary zinc and serum zinc and copper concentrations on the risk of fetal loss in 570 cows. three herds received no supplements (herds 1, 3, 4), while cows in herd 2 received supplements of either 7 g zinc week-1 (n = 118), as zinc methionine, or a control diet containing methionine (n = 128). Serum zinc, copper and metallothionein concentrations were determined once a month throughout gestation. Logistic regression and survival analysis were used to examine for associations between risk of fetal loss and serum zinc, copper, copper:zinc, or metallothionein concentrations, supplement level, and maternal age at conception. The risk of fetal loss increased when both serum zinc decreased and copper concentrations increased (P < 0.0001; relative risk = 10.28, 95% confidence intervals = 4.69, 22.5). The attributable risk, for a decline in the zinc concentration by 10 mumol l-1 and an increase in the copper concentration by 5 mumol l-1 was 90.27%. Methionine-supplemented cows had a higher risk of fetal loss compared with zinc-methionine-supplemented cows (one-tailed P = 0.0375; relative risk = 2.98). Cows in herds 1, 3 and 4 had a higher risk for abortion than did zinc-methionine-supplemented cows in herd 2 (relative risk = 26.27, 95% confidence intervals = 2.31, 299.38; relative risk = 40.87, 95% confidence intervals = 3.50, 458.43; relative risk = 41.53, 95% confidence intervals = 3.77, 457.02, respectively). Our results suggest that inflammation and zinc nutriture may play an important role in fetal loss in dairy cows.