A fluorescent chemical sensor for Fe3+ based on blocking of intramolecular proton transfer of a quinazolinone derivative.
A fluorescent chemical sensor for Fe3+ based on blocking of intramolecular proton transfer of a quinazolinone derivative.
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DOI：
10.1016/j.talanta.2006.03.036
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发表时间：
2007-01
期刊：
影响因子：
6.1
通讯作者：
Xiaobing Zhang;G. Cheng;Wei-Jun Zhang;G. Shen;R. Yu
中科院分区：
文献类型：
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作者：
Xiaobing Zhang;G. Cheng;Wei-Jun Zhang;G. Shen;R. Yu
本文合成了具有激发态分子内质子转移（ESIPT）反应和良好物理化学性质的典型化合物2-（2′-羟基苯基）-4（3 H）-喹唑啉酮（HPQ），并将其用作Fe 3+敏感光化学传感器的荧光离子载体。Fe 3+的加入使HPQ膜的荧光强度降低，这是由于Fe 3+阻断了HPQ的ESIPT反应，使其荧光猝灭。研究了传感膜组成对传感效果的影响，优化了实验条件。该传感器在7.1×10− 7 M至1.4×10− 4 M的浓度范围内对Fe 3+呈线性响应，检测限为8.0×10− 8 M，工作pH范围为2.5至4.5。它对Fe 3+的选择性优于大量的阳离子，如碱金属、碱土金属和过渡金属离子。将该传感器应用于药物样品中铁离子含量的测定，结果令人满意。
In this paper, 2-(2′-hydroxy-phenyl)-4(3H)-quinazolinone (HPQ), a typical compound that exhibits excited state intramolecular proton transfer (ESIPT) reaction and possesses good photophysical properties, is synthesized and used as fluoroionophore for Fe3+sensitive optochemical sensor. The decrease of fluorescence intensity of HPQ membrane upon the addition of Fe3+was attributed to the blocking of ESIPT reactions of HPQ and quenching its fluorescence. The effect of the composition of the sensing membrane was studied, and experimental conditions were optimized. The sensor shows a linear response toward Fe3+in the concentration range of 7.1×10−7M to 1.4×10−4M with a limit of detection of 8.0×10−8M, and a working pH range from 2.5 to 4.5. It shows excellent selectivity for Fe3+over a large number of cations such as alkali, alkaline earth and transitional metal ions. The proposed sensor is applied to the determination of the content of iron ions in pharmaceutical preparations samples with satisfactory results.