Predictors of antral follicle count during the reproductive years.
Predictors of antral follicle count during the reproductive years.
复制标题
生育期内窦卵泡计数的预测因子。
DOI：
10.1093/humrep/dei048
复制
发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Levin,B
中科院分区：
文献类型：
--
作者：
Kline,J;Kinney,A;Kelly,A;Reuss,ML;Levin,B
背景：我们试图确定有腔卵泡计数的指标，这将有助于临床医生在不依赖超声计数的情况下估计卵巢卵泡的数量。方法：对176例初孕妇女的年龄、卵巢体积、卵泡刺激素(FSH)、二聚体抑制素B和雌二醇四项潜在年龄指标与有腔卵泡计数的关系进行分析。我们确定了最能预测低腔卵泡数量(≤10个卵泡)的回归模型。结果：年龄、卵巢体积、卵泡刺激素和抑制素B均与有腔卵泡数显著相关。53例(30.1%)有≤-10有腔卵泡。在总样本中，在对应于80%敏感度的切点，包含所有四个变量的回归模型的阳性预测值为60%。所有回归模型在35岁的女性(13.9%，低计数)中的表现不如在35岁的女性≥(52.0%，低计数)。在老年女性中，包含所有四个变量的模型的阳性预测值为79%，而仅有按年龄排列的模型的阳性预测值为60%。结论：我们的模型为正在尝试怀孕或希望了解是否可以推迟生育的35岁≥女性提供了建议基础。
BACKGROUND: We sought to identify indicators of antral follicle count which would be serviceable to clinicians seeking to estimate the number of ovarian follicles without relying on sonographic counts. METHODS: We examined the relations of chronological age and four potential indicators of ovarian age—ovarian volume, FSH, dimeric inhibin B and estradiol—to antral follicle count in 176 recently pregnant women. We identified the regression models which best predict low antral follicle count (≤10 follicles). RESULTS: Chronological age, ovarian volume, FSH and inhibin B were each significantly associated with antral follicle count. Fifty-three (30.1%) women had ≤10 antral follicles. In the total sample, at the cutpoint corresponding to 80% sensitivity, the positive predictive value for a regression model with all four variables was 60%. All regression models performed less well in women <35 years (13.9% with low count) than in women ≥35 years (52.0% with low count). In older women, the positive predictive value for the model with all four variables was 79%, compared with 60% for a model with chronological age alone. CONCLUSIONS: Our models provide a basis for advising women aged ≥35 years who are either trying to conceive or wish to learn whether they may postpone childbearing.