Oral Human Papillomavirus Infection and Its Risk Factors among 5,410 Healthy Adults in China, 2009-2011
Oral Human Papillomavirus Infection and Its Risk Factors among 5,410 Healthy Adults in China, 2009-2011
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DOI：
10.1158/1055-9965.epi-14-0084
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发表时间：
2014-10-01
影响因子：
3.8
通讯作者：
Ke, Yang
中科院分区：
文献类型：
--
作者：
Hang, Dong;Liu, Fangfang;Ke, Yang
背景资料：尽管口腔人乳头状瘤病毒（HPV）感染和口咽鳞状细胞癌（OSCC）的一个子集之间的联系，很少有人知道口腔HPV感染的流行病学健康成年人在China.Methods：口腔拭子标本和问卷调查收集了5,410个人（年龄25-65岁）。采用通用引物介导的PCR（SPF 1/GP 6+）方法检测口腔脱落细胞中的HPV DNA。结果：在5,351例β珠蛋白阳性标本中，α粘膜型HPV检出率为0.67%（95%CI，0.47%~ 0.93%），皮肤型HPV检出率为5.46%（95%CI，4.86%~ 6.10%）。HPV 16和3型分别是粘膜型（0.43%; 95% CI，0.27%-0.64%）和皮肤型（4.17%; 95% CI，3.65%-4.74%）最常见的HPV。粘膜HPV的患病率随着年龄的增加（25-65岁）从0.93%下降到0.36%（P趋势= 0.033），并且与自我报告的口腔疾病史相关[校正比值比（OR），4.78; 95%CI，1.07-21.41]。在1,614对异性恋夫妇中，发现一方皮肤HPV感染会增加另一方皮肤HPV感染的风险（校正OR为2.33; 95%CI为1.22-4.48）。年龄较小和有口腔疾病史意味着粘膜HPV感染的风险较高。影响：本研究解决了中国健康人群口腔HPV感染的流行病学数据匮乏的问题。(C)2014年AACR。
Background: Despite the established link between oral human papillomavirus (HPV) infection and a subset of oropharyngeal squamous cell carcinoma (OSCC), little is known about the epidemiology of oral HPV infection among healthy adults in China.Methods: Oral swab specimens and questionnaires were collected from 5,410 individuals (ages 25-65 years). HPV DNA in oral exfoliated cells was tested by general primer-mediated (SPF1/GP6+) PCR and sequencing. Univariate and multivariate analyses were performed to assess the associations between exposure factors and oral infection.Results: Alpha mucosal HPV types were detected in 0.67% [95% confidence interval (CI), 0.47%-0.93%] of 5,351 beta-globin-positive specimens, and cutaneous HPV in 5.46% (95% CI, 4.86%-6.10%). HPV16 and 3 were the most prevalent types of a mucosal (0.43%; 95% CI, 0.27%-0.64%) and cutaneous HPV (4.17%; 95% CI, 3.65%-4.74%), respectively. The prevalence of a mucosal HPV decreased with increasing age (25-65 years) from 0.93% to 0.36% (P-trend = 0.033), and was associated with self-reported history of oral disease [adjusted odds ratio (OR), 4.78; 95% CI, 1.07-21.41]. In 1,614 heterosexual couples, cutaneous HPV in one partner was found to increase the other partner's risk of cutaneous HPV infection (adjusted OR, 2.33; 95% CI, 1.22-4.48).Conclusions: Oral HPV infection, particularly with a mucosal types, is rare among healthy adults in China. A younger age and a history of oral disease imply higher risk of a mucosal HPV infection.Impact: This study addresses the paucity of epidemiological data on oral HPV infection among healthy population in China. (C) 2014 AACR.