Prophylactic augmentin in prelabor preterm rupture of the membranes
Prophylactic augmentin in prelabor preterm rupture of the membranes
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DOI：
10.1016/s0020-7292(99)00036-3
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发表时间：
1999-06-01
影响因子：
3.8
通讯作者：
Mujaji, C
中科院分区：
文献类型：
--
作者：
Magwali, TL;Chipato, T;Mujaji, C
目的：确定在未足月胎膜早破中预防性使用 Augmentin 是否可以延长妊娠并降低脓毒症引起的新生儿和孕产妇发病率。方法：研究地点是津巴布韦哈拉雷妇产医院。妊娠 26 至 36 周患有未足月胎膜早破的女性被随机分配到一组，接受一个疗程的预防性口服奥格门汀治疗，另一组则不接受预防性抗生素治疗。计算得出的样本量为每组 72 名女性。使用 EPI INFO 程序分析数据。结果：共有 171 名女性被纳入研究，其中 84 名属于 Augmentin 组，87 名属于无治疗组。接受预防性奥格门汀治疗的组在胎膜破裂和分娩之间的潜伏期明显更长。在不治疗组中，败血症导致的新生儿和孕产妇发病率有增加的趋势，但未达到统计学显着性。结论：在未足月胎膜早破中预防性使用 Augmentin 可显着延长妊娠时间。它似乎可以降低败血症引起的新生儿和孕产妇发病率。 (C) 1999 年国际妇产科联合会。
Objective: To determine whether the use of prophylactic Augmentin in PPROM prolongs gestation and reduces neonatal and maternal morbidity due to sepsis. Method: Study setting was Harare Maternity Hospital, Zimbabwe. Women with PPROM between 26 and 36 weeks' gestation were randomly allocated either to a group given a course of prophylactic oral Augmentin or another receiving no prophylactic antibiotic treatment. The calculated sample size was 72 women per group. Data were analyzed using the EPI INFO program. Results: A total of 171 women were recruited into the study, 84 in the Augmentin group and 87 in the No Treatment group. The group receiving prophylactic Augmentin had a significantly longer latency period between rupture of membranes and delivery. There was a trend towards increased neonatal and maternal morbidity due to sepsis in the No Treatment group although no statistical significance was reached. Conclusion: The use of prophylactic Augmentin in PPROM significantly prolongs gestation. It appears to decrease neonatal and maternal morbidity due to sepsis. (C) 1999 International Federation of Gynecology and Obstetrics.