Mechanism of thyroid hormone action
Mechanism of thyroid hormone action
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DOI：
10.1089/105072502760143791
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发表时间：
2002-06-01
期刊：
影响因子：
6.6
通讯作者：
Williams, GR
中科院分区：
文献类型：
--
作者：
Harvey, CB;Williams, GR
甲状腺激素（三碘甲状腺原氨酸[T-3]）通过与高亲和力核受体结合来调节基因表达。甲状腺激素受体（TRs）识别T-3靶基因启动子中的特异性反应元件序列，并响应于激素激活或抑制转录。在本文中，我们回顾了TR蛋白和甲状腺激素反应元件（TRES），它们结合，TRS的作用机制结合TRE在基础和配体构象，以及这些复合物中涉及的相互作用蛋白。然后，我们简要地考虑了与其他信号通路的串扰，并介绍了T-3也可能通过位于膜上的非基因组作用迅速发挥作用的想法。我们讨论了各种TR亚型的基因表达模式和具体行动，并考虑新的TR亚型特异性配体。
Thyroid hormone (triiodothyronine [T-3]) regulates gene expression by binding to high-affinity nuclear receptors. Thyroid hormone receptors (TRs) recognize specific response element sequences in the promoters of T-3-target genes and activate or repress transcription in response to hormone. In this paper, we review the TR proteins and thyroid hormone response elements (TREs) to which they bind, the mechanisms of action of TRs bound to the TRE in basal and liganded conformations, and the interacting proteins implicated in these complexes. We then briefly consider the cross-talk with other signaling pathways and introduce the idea that T-3 may also act rapidly via nongenomic actions located on membranes. We discuss patterns of gene expression and specific actions of the various TR isoforms and consider the novel TR isoform specific ligands.