THE SICKLE-CELL AND HAEMOGLOBIN-C GENES IN SOME AFRICAN POPULATIONS
THE SICKLE-CELL AND HAEMOGLOBIN-C GENES IN SOME AFRICAN POPULATIONS
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DOI：
10.1111/j.1469-1809.1971.tb00266.x
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发表时间：
1956-01-01
影响因子：
1.9
通讯作者：
ALLISON, AC
中科院分区：
文献类型：
--
作者：
ALLISON, AC
The presence or absence of sickling of red blood cells and electro-phoretic mobility of hemoglobin was investigated in 729 infants between 2 months and 1 year of age and 3602 parents and other adults from various East and West African territories. The distribution of the sickle-cell and hemoglobin C genes in the Gambia, Sierra Leone, Nigeria and the Gold Coast is described. In the district of Musoma, Tanganyika, and in various populations from the Gambia, the incidence of sickle-cell homozygotes in infant populations was found to be close to that expected from the Hardy-Weinberg law. In the adults, however, there was a highly significant deficiency of homozygotes. From available data it is estimated that the viability of the sickle-cell homozygote is of the order of one-fifth that of other genotypes in both East and West Africa.
