Non coding RNAs in aortic aneurysmal disease.
Non coding RNAs in aortic aneurysmal disease.
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DOI：
10.3389/fgene.2015.00125
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发表时间：
2015
影响因子：
3.7
通讯作者：
Emanueli C
中科院分区：
文献类型：
--
作者：
Duggirala A;Delogu F;Angelini TG;Smith T;Caputo M;Rajakaruna C;Emanueli C
动脉瘤是血管壁的局部扩张，其直径约为原直径的50%。在心血管疾病的范围内，主动脉瘤是最具挑战性的治疗之一。大多数患者在动脉瘤破裂或先前无症状的情况下剥离后急性出现，并通过开放手术或血管内修复进行治疗。此外，患者可能并发疾病禁忌症手术干预。总的来说，这些因素促使人们寻找其他方法，使用侵入性较小的方法来识别、监测和治疗动脉瘤。非编码RNA （ncRNAs）正逐渐成为基因表达的新的基本调控因子。小microrna开辟了ncrna领域，引起了基础和临床科学家的关注，因为它们有可能成为主动脉瘤的新治疗靶点和临床生物标志物。最近，人们开始积极研究长链ncRNAs (lncRNAs)，并首次发表了令人兴奋的报告，进一步表明它们对血管生理学和疾病的重要贡献，但在很大程度上尚未被探索。本文就ncRNA的不同类型及其在主动脉动脉瘤中的作用作一综述。我们讨论了针对ncrna的治疗干预的潜力，并描述了允许控制动脉瘤进展的机制研究和临床翻译尝试的研究模型。此外，我们还讨论了microrna和lncrna作为临床生物标志物的潜在作用。
An aneurysm is a local dilatation of a vessel wall which is >50% its original diameter. Within the spectrum of cardiovascular diseases, aortic aneurysms are among the most challenging to treat. Most patients present acutely after aneurysm rupture or dissection from a previous asymptomatic condition and are managed by open surgical or endovascular repair. In addition, patients may harbor concurrent disease contraindicating surgical intervention. Collectively, these factors have driven the search for alternative methods of identifying, monitoring and treating aortic aneurisms using less invasive approaches. Non-coding RNA (ncRNAs) are emerging as new fundamental regulators of gene expression. The small microRNAs have opened the field of ncRNAs capturing the attention of basic and clinical scientists for their potential to become new therapeutic targets and clinical biomarkers for aortic aneurysm. More recently, long ncRNAs (lncRNAs) have started to be actively investigated, leading to first exciting reports, which further suggest their important and yet largely unexplored contribution to vascular physiology and disease. This review introduces the different ncRNA types and focus at ncRNA roles in aorta aneurysms. We discuss the potential of therapeutic interventions targeting ncRNAs and we describe the research models allowing for mechanistic studies and clinical translation attempts for controlling aneurysm progression. Furthermore, we discuss the potential role of microRNAs and lncRNAs as clinical biomarkers.
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DOI：
10.1042/cs20090372
发表时间：
2010-03-09
期刊：
Clinical science (London, England : 1979)
影响因子：
--
作者：
Daugherty A;Rateri DL;Charo IF;Owens AP;Howatt DA;Cassis LA
通讯作者：
Cassis LA
影响因子：
64.8
作者：
Cordes KR;Sheehy NT;White MP;Berry EC;Morton SU;Muth AN;Lee TH;Miano JM;Ivey KN;Srivastava D
通讯作者：
Srivastava D
DOI：
10.1161/atvbaha.114.303240
发表时间：
2014-06
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Bell RD;Long X;Lin M;Bergmann JH;Nanda V;Cowan SL;Zhou Q;Han Y;Spector DL;Zheng D;Miano JM
通讯作者：
Miano JM
影响因子：
9.8
作者：
Bown, Matthew J.;Jones, Gregory T.;Samani, Nilesh J.
通讯作者：
Samani, Nilesh J.
影响因子：
--
作者：
Coady, MA;Davies, RR;Elefteriades, JA
通讯作者：
Elefteriades, JA