Air nicotine and saliva cotinine as indicators of workplace passive smoking exposure and risk
Air nicotine and saliva cotinine as indicators of workplace passive smoking exposure and risk
复制标题
DOI：
10.1111/j.1539-6924.1998.tb00917.x
复制
发表时间：
1998-02-01
期刊：
影响因子：
3.8
通讯作者：
Hammond, SK
中科院分区：
文献类型：
--
作者：
Repace, JL;Jinot, J;Hammond, SK
我们从办公室空气中的环境烟草烟雾(ETS)和不吸烟的美国员工的唾液可替宁中模拟尼古丁。我们估计：唾液中平均0.4 ng/ml的可替宁水平相当于肺癌和心脏病的终身死亡风险增加1/1000和1/100；暴露于ETS的上班族中95%的人超过OSHA的心脏病死亡显著风险水平，60%超过肺癌死亡的显著风险水平；办公室工作场所被动吸烟导致的4000例心脏病死亡和400例肺癌死亡，而目前办公室工作场所无限制吸烟的流行率为28%。
We model nicotine from environmental tobacco smoke (ETS) in office air and salivary cotinine in nonsmoking U.S. workers. We estimate that: an average salivary cotinine level of 0.4 ng/ml corresponds to an increased lifetime mortality risk of 1/1000 for lung cancer, and 1/100 for heart disease; >95% of ETS-exposed office workers exceed OSHA's significant risk level for heart disease mortality, and 60% exceed significant risk for lung cancer mortality; 4000 heart disease deaths and 400 lung cancer deaths occur annually among office workers from passive smoking in the workplace, at the current 28% prevalence of unrestricted smoking in the office workplace.