Presence of two members of c-erbA receptor gene family (c-erbA beta and c-erbA2) in smallest region of somatic homozygosity on chromosome 3p21-p25 in human breast carcinoma.
Presence of two members of c-erbA receptor gene family (c-erbA beta and c-erbA2) in smallest region of somatic homozygosity on chromosome 3p21-p25 in human breast carcinoma.
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人乳腺癌染色体 3p21-p25 上体细胞纯合性最小区域存在 c-erbA 受体基因家族的两个成员（c-erbA beta 和 c-erbA2）。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
R. Callahan
中科院分区：
文献类型：
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作者：
I. Ali;R. Lidereau;R. Callahan
人类乳腺癌中3号染色体短臂（3 p）上基因的杂合性丢失发生在涉及其他恶性肿瘤的区域，包括肾细胞癌、肺癌和von Hippel-Lindau病。这一发现表明存在一种在多种癌症中起关键作用的基因。在我们对84例信息性（杂合性）原发性乳腺肿瘤的研究中，30%显示3号染色体杂合性丢失。原发性乳腺肿瘤中最短的纯合性区域位于3号染色体短臂上3 p21-p25区域的DNF 15 S2和RAF 1基因座之间。该区域包括至少两个c-erbA类固醇/甲状腺激素受体家族成员（c-erbA β和c-erbA 2），可能与乳腺癌特别相关。此外，先前报道3号染色体基因杂合性缺失的肿瘤在11号染色体p上有频繁的等位基因缺失和c-myc原癌基因扩增。这些结果突出了乳腺肿瘤中多种遗传改变的发生。
The loss of heterozygosity of genes on the short arm of chromosome 3 (3p) in human breast carcinomas occurs in a region involved in other malignancies, including renal cell carcinoma, lung cancers, and von Hippel-Lindau disease. This finding suggests the presence of a gene(s) that plays a crucial role in multiple cancers. In our study of 84 informative (heterozygous) primary breast tumors, 30% showed losses of heterozygosity on chromosome 3. The shortest region of homozygosity in primary human breast tumor is located between the DNF15S2 and RAF1 loci in the 3p21-p25 region on the short arm of chromosome 3. This region includes at least two members of the c-erbA steroid/thyroid hormone receptor family (c-erbA beta and c-erbA2) that may be of special relevance to breast cancer. Furthermore, tumors with a loss of heterozygosity of genes on chromosome 3 were previously reported to have frequent allelic deletions on chromosome 11p and amplification of the c-myc proto-oncogene. These results highlight the occurrence of multiple genetic alterations in breast tumors.