Low meprin α expression differentiates primary ovarian mucinous carcinoma from gastrointestinal cancers that commonly metastasise to the ovaries
Low meprin α expression differentiates primary ovarian mucinous carcinoma from gastrointestinal cancers that commonly metastasise to the ovaries
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DOI：
10.1136/jcp.2005.034223
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发表时间：
2007-06-01
影响因子：
3.4
通讯作者：
O'Brien, Philippa M.
中科院分区：
文献类型：
--
作者：
Heinzelmann-Schwarz, Viola A.;Scolyer, Richard A.;O'Brien, Philippa M.
背景资料：目前，没有特异性免疫组化标记可用于区分原发性粘液上皮性卵巢癌（MOC）和转移到卵巢的其他部位的腺癌，这可能对患者的治疗和预后产生影响。目的：研究两种肠道标记物半乳糖凝集素4和甲氧苄氨嘧啶在卵巢和胃肠道粘液癌中的表达。方法：用免疫组化分析，半乳糖凝集素4和meprin a的表达进行了研究，在10个MOCs和38个粘液腺癌的结肠，胰腺，胃和阑尾，最常见的网站的起源卵巢transferations.Results：总胞浆半乳糖凝集素4的表达是相对一致的不同癌之间。与胃肠道癌相比，MOCs的膜meprin a表达显著降低。此外，Meprin A的表达表现出更大的歧视卵巢癌和胃肠道癌比细胞角蛋白CK7和CK20，目前的标准免疫组化标记物，用于确定粘液癌的组织起源涉及ovaries.Conclusions：Meprin A是一个有用的额外的标志物，在区分原发性继发性粘液腺癌的卵巢。
Background: Currently, no specific immunohistochemical markers are available to differentiate primary mucinous epithelial ovarian cancer (MOC) from adenocarcinomas originating at other sites that have metastasised to the ovary, which may have an impact on patient management and prognosis.Aim: To investigate the expression of two intestinal markers, galectin 4 and meprin a, in mucinous carcinomas of the ovary and gastrointestinal tract.Methods: Using immunohistochemical analysis, the expression of galectin 4 and meprin a was investigated in 10 MOCs and in 38 mucinous adenocarcinomas of colon, pancreas, stomach and appendix, the most common sites of origin of ovarian metastases.Results: Total cytoplasmic galectin 4 expression was relatively consistent between the different carcinomas. Membranous meprin a expression was significantly lower in MOCs compared with gastrointestinal carcinomas. Moreover, meprin a expression showed greater discrimination between the ovarian and gastrointestinal carcinomas than the cytokeratins CK7 and CK20, the current standard immunohistochemical markers used to determine the tissue origin of mucinous carcinomas involving the ovaries.Conclusions: Meprin a is a useful additional marker in differentiating primary from secondary mucinous adenocarcinomas of the ovary.