NORMAL HISTOLOGY OF THE PROSTATE
NORMAL HISTOLOGY OF THE PROSTATE
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DOI：
10.1097/00000478-198808000-00003
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发表时间：
1988-08-01
影响因子：
5.6
通讯作者：
MCNEAL, JE
中科院分区：
文献类型：
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作者：
MCNEAL, JE
前列腺包含三个主要的腺区——外周区、中央区和过渡区，它们在组织学和生物学上都是不同的。中央区对癌和其他疾病的抵抗力相对较强；过渡区是前列腺增生的主要起源部位。也有几个重要的非腺体区域集中在腺体的前内侧部分。每个腺区都有特定的建筑和基质特征。在所有区，导管和腺泡均被分泌上皮所衬。在每个区，分泌层下面有一层基底细胞，以及散布的内分泌旁分泌细胞。与正常组织学的常见偏差包括炎症后萎缩、基底细胞增生、良性结节增生、非典型腺瘤增生和导管腺泡发育不良。这些病变有时可能与癌混淆，特别是在活检材料中。
The prostate gland contains three major glandular regions—the peripheral zone, the central zone, and the transition zone—which differ histologically and biologically. The central zone is relatively resistant to carcinoma and other disease; the transition zone is the main site of origin of prostate hyperplasia. There are also several important nonglandular regions concentrated in the antero-medial portion of the gland. Each glandular zone has specific architectural and stromal features. In all zones, both ducts and acini are lined by secretory epithelium. In each zone, there is a layer of basal cells beneath the secretory lining, as well as interspersed endocrine-paracrine cells. Frequent deviations from normal histology include post-inflammatory atrophy, basal cell hyperplasia, benign nodular hyperplasia, atypical adenomatous hyperplasia, and duct-acinar dysplasia. These lesions may at times be confused with carcinoma, especially in biopsy material.