THE EXOGENOUS ORIGIN OF TRIMETHYLAMINE IN THE MOUSE
THE EXOGENOUS ORIGIN OF TRIMETHYLAMINE IN THE MOUSE
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DOI：
10.1016/0026-0495(92)90140-6
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发表时间：
1992-02-01
影响因子：
9.8
通讯作者：
SMITH, RL
中科院分区：
文献类型：
--
作者：
ALWAIZ, M;MIKOV, M;SMITH, RL
尽管现在普遍认为尿三甲胺 (TMA) 的来源是通过肠道微生物群对胆碱等前体的作用，但几乎没有直接证据。无菌小鼠中尿液中 TMA 的正常生成不存在，而经过抗生素预处理的动物中则大大减少。无菌小鼠与传统动物的同居恢复了它们排泄TMA的能力。这项研究揭示了肠道微生物群在从食物中的前体提供 TMA 方面的基本作用。
Although it is now generally regarded that the origin of urinary trimethylamine (TMA) is via the action of intestinal microflora on precursors such as choline, little direct evidence exists. The normal production of urinary TMA was shown to be absent in germ-free mice and greatly reduced in antibiotic-pretreated animals. Cohabitation of germ-free mice with conventional animals restored their ability to excrete TMA. This study invokes a fundamental role for the intestinal microflora in the provision of TMA from precursors within the food.