Hypothalamic regulation of pituitary gonadotropin-releasing hormone receptors: effects of hypothalamic lesions and a gonadotropin-releasing hormone antagonist.
Hypothalamic regulation of pituitary gonadotropin-releasing hormone receptors: effects of hypothalamic lesions and a gonadotropin-releasing hormone antagonist.
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垂体促性腺激素释放激素受体的下丘脑调节：下丘脑病变和促性腺激素释放激素拮抗剂的影响。
DOI：
10.1210/endo-110-4-1108
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发表时间：
1982
期刊：
影响因子：
4.8
通讯作者：
K. Catt
中科院分区：
文献类型：
--
作者：
R. Clayton;K. Channabasavaiah;J. Stewart;K. Catt
通过阻断内源性促性腺激素释放激素（GnRH）分泌，随后分析垂体切除术后受体和血清LH反应，研究下丘脑在维持垂体促性腺激素释放激素受体（GnRH-R）和促性腺激素分泌中的作用。还检查了持续输注强效GnRH拮抗剂类似物[N-乙酰基-Ala 1，D-p-chloro-Phe 2，D-Trp 3，6]GnRH对这些相同反应的影响。在去势后6天测量，前列腺切除术前正中隆起破坏可防止GnRH-R增加2倍和血清LH增加10倍。正中隆起病变（MEL）动物的GnRH-R值比正常对照组低30%（P < 0.01）。在慢性前列腺切除动物中，MEL也降低了GnRH-R和血清LH值，低于完整对照组。外源性促性腺激素释放激素（GnRH）单独给药于MEL荷瘤慢性去势大鼠，可逆转病变的影响，促性腺激素释放激素受体（GnRH-R）和血清促黄体生成素（LH）恢复到去势对照组水平。
The role of the hypothalamus in maintenance of pituitary gonadotropin-releasing hormone receptors (GnRH-R) and gonadotropin secretion was investigated by ablation of endogenous GnRH secretion and subsequent analysis of the receptor and serum LH responses to orchidectomy. The effects of continuous infusion of a potent GnRH antagonist analog, [N-acetyl- Ala1,D-p-chloro-Phe2,D-Trp3,6]GnRH, upon these same responses were also examined. Median eminence destruction before orchidectomy prevented the characteristic 2-fold increase in GnRH-R and 10-fold increase in serum LH, measured 6 days post castration. GnRH-R values in the median eminence lesion (MEL)-bearing animals were 30% (P < 0.01) lower than in the intact controls. In chronically orchidectomized animals, MEL also reduced GnRH-R and serum LH values to below those of intact controls. Exogenous GnRH administration alone to MEL-bearing chronically castrated rats reversed the effects of the lesion, with GnRH-R and serum LH being restored to castrate control ...