Target validation using chemical probes
Target validation using chemical probes
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DOI：
10.1038/nchembio.1197
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发表时间：
2013-04-01
影响因子：
14.8
通讯作者：
Jones, Lyn H.
中科院分区：
文献类型：
--
作者：
Bunnage, Mark E.;Chekler, Eugene L. Piatnitski;Jones, Lyn H.
全面分析的化学探针对于支持严格的临床前靶标验证所必需的生物实验的公正解释至关重要。我们相信，通过开发“化学探针工具箱”及其使用框架，化学生物学可以在识别与疾病潜在相关的靶标方面发挥更重要的作用，避免目前实践中使靶标验证复杂化的许多偏见。
Fully profiled chemical probes are essential to support the unbiased interpretation of biological experiments necessary for rigorous preclinical target validation. We believe that by developing a 'chemical probe tool kit', and a framework for its use, chemical biology can have a more central role in identifying targets of potential relevance to disease, avoiding many of the biases that complicate target validation as practiced currently.