Occupational exposure to welding fume among welders: Alterations of manganese, iron, zinc, copper, and lead in body fluids and the oxidative stress status
Occupational exposure to welding fume among welders: Alterations of manganese, iron, zinc, copper, and lead in body fluids and the oxidative stress status
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DOI：
10.1097/01.jom.0000116900.49159.03
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发表时间：
2004-03-01
影响因子：
3.2
通讯作者：
Zheng, W
中科院分区：
文献类型：
--
作者：
Li, GJJ;Zhang, LL;Zheng, W
在这项研究中，焊工从汽车制造商选择，对照组是从附近的食品厂。电焊工和对照组呼吸区的空气锰含量分别为1.45 +/-SD 1.08 mg/m3和0.11 +/- 0.07 mug/m3。电焊工血清锰、铁含量分别为对照组的4.3倍和1.9倍。焊工血铅浓度增加2.5倍，而血清锌水平下降1.2倍，与对照组相比。线性回归显示，五种金属的血液水平和焊工的年龄之间缺乏关联。此外，焊工红细胞超氧化物歧化酶活性和血清丙二醛水平分别比对照组低24%和高78%。这些研究结果表明，职业暴露于焊接烟雾中的焊工扰乱了体内微量元素的平衡，在体循环和诱导氧化应激。
Welders in this study were selected from a vehicle manufacturer; control subjects were from a nearby food factory. Airborne manganese levels in the breathing zones of welders and controls were 1.45 +/- SD1.08 mg/m(3) and 0.11 +/- 0.07 mug/m(3), respectively. Serum levels of manganese and iron in welders were 4.3-fold and 1.9-fold, respectively, higher than those of controls. Blood lead concentrations in welders increased 2.5-fold, whereas serum zinc levels decreased 1.2-fold, in comparison with controls. Linear regression revealed the lack of associations between blood levels of five metals and welder's age. Furthermore, welders had erythrocytic superoxide dismutase activity and serum malondialdehyde levels 24% less and 78% higher, respectively, than those of controls. These findings suggest that occupational exposure to welding fumes among welders disturbs the homeostasis of trace elements in systemic circulation and induces oxidative stress.