Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. II. Studies with herpes simplex, Moloney sarcoma, vesicular stomatitis, Newcastle disease, and influenza viruses
Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. II. Studies with herpes simplex, Moloney sarcoma, vesicular stomatitis, Newcastle disease, and influenza viruses
复制标题
通过使用抗干扰素血清证明了干扰素在小鼠病毒性疾病发病机制中的作用。
DOI：
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发表时间：
1976
影响因子：
15.3
通讯作者：
Marie
中科院分区：
文献类型：
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作者：
I. Gresser;M. Tovey;C. Maury;Marie
本文研究了绵羊抗鼠干扰素球蛋白对几种不同病毒性疾病的治疗效果。在抗干扰素球蛋白治疗的小鼠腹腔内感染单纯疱疹病毒（HSV）I型，潜伏期缩短，总LD 50增加了几百倍，相比病毒感染的对照小鼠。当HSV皮下接种时，所有抗干扰素球蛋白治疗的小鼠死亡，而只有5%的病毒感染的对照小鼠死亡。随后用抗干扰素球蛋白对先前HSV感染的小鼠进行治疗并没有导致HSV的再激活。用抗干扰素球蛋白治疗成年小鼠导致MSV诱导的肿瘤更早出现，更多的小鼠携带肿瘤，肿瘤大小增加，肿瘤持续时间增加。尽管再次注射抗干扰素球蛋白，所有肿瘤最终均消退。抗干扰素球蛋白治疗导致接种VSV（鼻内）的成年小鼠和感染NDV的新生小鼠迅速发病和死亡。抗干扰素球蛋白对流感病毒感染小鼠的病程无影响。我们的结论是，早期产生的干扰素是一个重要因素，在小鼠的反应，几种病毒表现出不同的病因。
The effect of potent sheep anti-mouse interferon globulin was investigated in several different experimental virus diseases of mice. In anti-interferon globulin-treated mice infected intraperitoneally with herpes simplex virus (HSV) type I, the latent period was shortened, and the overall LD50 was increased several hundredfold compared to virus-infected control mice. When HSV was inoculated subcutaneously all anti-interferon globulin-treated mice died, whereas only 5% of virus-infected control mice died. Subsequent treatment with anti-interferon globulin of previously HSV-infected mice did not result in reactivation of HSV. Treatment of adult mice with anti-interferon globulin resulted in an earlier appearance of MSV-induced tumors, a greater number of mice bearing tumors, an increase in tumor size, and an increase in the duration of tumors. All tumors eventually regressed despite reinjection of anti-interferon globulin. Anti-interferon globulin treatment resulted in a rapid onset of disease and death in adult mice inoculated (intranasal) with VSV and in newborn mice infected with NDV. Anti-interferon globulin exerted no effect on the course of influenza virus infection of mice. We conclude that the early production of interferon is an importane element in the response of the mouse to several viruses exhibiting different pathogeneses.