Increased-resolution OCT thickness mapping of the human macula: A statistically based registration
Increased-resolution OCT thickness mapping of the human macula: A statistically based registration
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DOI：
10.1167/iovs.07-0467
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发表时间：
2008-05-01
影响因子：
4.4
通讯作者：
Cunha-Vaz, Jose
中科院分区：
文献类型：
--
作者：
Bernardes, Rui;Santos, Torcato;Cunha-Vaz, Jose
目的.为了描述增强Stratus OCT的视网膜厚度图的空间分辨率的技术的开发（Carl Zeiss Meditec，Inc.，都柏林，CA）。计算视网膜厚度图谱（RT-atlas）模板，建立黄斑坐标系。RT-atlas是从健康志愿者获得的视网膜厚度分析仪（RTA）图的主成分分析中开发的。在RT图谱上记录Stratus OCT径向厚度测量值，由此计算改进的黄斑厚度图。此后，在先前计算的标测图上配准Stratus OCT圆形扫描，以增强空间分辨率。将所开发的技术应用于健康志愿者和糖尿病视网膜病变（DR）或年龄相关性黄斑变性（AMD）患者的Stratus OCT厚度数据。结果显示，对于正常或接近正常的健康志愿者和DR患者的黄斑厚度图，该技术可以作为确定视网膜厚度的重要辅助手段。目前正在努力改善AMD患者视网膜厚度数据的登记。所开发的技术增强了对Stratus OCT采集的数据的评估，有助于检测早期视网膜厚度异常。此外，从该技术获得的视网膜厚度测量的标准数据库，如参考黄斑坐标系，可以创建而没有由错过固定和眼睛倾斜引起的误差。
PURPOSE. To describe the development of a technique that enhances spatial resolution of retinal thickness maps of the Stratus OCT (Carl Zeiss Meditec, Inc., Dublin, CA). A retinal thickness atlas (RT-atlas) template was calculated, and a macular coordinate system was established, to pursue this objective.METHODS. The RT-atlas was developed from principal component analysis of retinal thickness analyzer (RTA) maps acquired from healthy volunteers. The Stratus OCT radial thickness measurements were registered on the RT-atlas, from which an improved macular thickness map was calculated. Thereafter, Stratus OCT circular scans were registered on the previously calculated map to enhance spatial resolution.RESULTS. The developed technique was applied to Stratus OCT thickness data from healthy volunteers and from patients with diabetic retinopathy (DR) or age-related macular degeneration (AMD). Results showed that for normal, or close to normal, macular thickness maps from healthy volunteers and patients with DR, this technique can be an important aid in determining retinal thickness. Efforts are under way to improve the registration of retinal thickness data in patients with AMD.CONCLUSIONS. The developed technique enhances the evaluation of data acquired by the Stratus OCT, helping the detection of early retinal thickness abnormalities. Moreover, a normative database of retinal thickness measurements gained from this technique, as referenced to the macular coordinate system, can be created without errors induced by missed fixation and eye tilt.