The interplay between sleeplessness and high-sensitivity C-reactive protein on risk of chronic musculoskeletal pain: longitudinal data from the Tromso Study

The interplay between sleeplessness and high-sensitivity C-reactive protein on risk of chronic musculoskeletal pain: longitudinal data from the Tromso Study
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DOI：
10.1093/sleep/zsz127
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发表时间：
2019-09-01
期刊：
SLEEP
影响因子：
5.6
通讯作者：
Nilsen, Kristian Bernhard
Nilsen, Kristian Bernhard
中科院分区：
医学2区
文献类型：
--
作者：
Skarpsno, Eivind Schjelderup;Mork, Paul Jarle;Nilsen, Kristian Bernhard

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研究目的：研究失眠和超敏C反应蛋白(HsCRP)与慢性肌肉骨骼痛风险的独立相关性，并探讨失眠和hsCRP对慢性肌肉骨骼痛风险的联合作用。方法：对32 14名女性和3 142名男性(平均年龄：55.4岁，范围：32~87岁)进行了一项基于人群的前瞻性研究，其中hsCRP=3.00 mg/L，经常或经常失眠，hsCRP和GT均为2.47(95%CI：1.79~3.40)；=3.00 mg/L，相应的RRS分别为1.89(95%CI：1.27~2.83)、0.96(95%CI：0.68~1.37)和2.83(95%CI：1.91~4.20)。
Study Objectives: To examine independent associations of sleeplessness and high-sensitivity C-reactive protein (hsCRP) with risk of chronic musculoskeletal pain, and to explore the joint effect of sleeplessness and hsCRP on risk of chronic musculoskeletal pain.Methods: A population-based prospective study of 3214 women and 3142 men (mean age: 55.4, range: 32-87) without severe chronic musculoskeletal pain and with hsCRP = 3.00 mg/L; and 2.47 (95% CI: 1.79-3.40) if they had both often/always sleeplessness and hsCRP >= 3.00 mg/L. The corresponding RRs for CWP were 1.89 (95% CI: 1.27-2.83), 0.96 (95% CI: 0.68-1.37), and 2.83 (95% CI: 1.91-4.20), respectively.Conclusions: These results suggest that there is an interplay between sleeplessness and hsCRP on risk of any chronic musculoskeletal pain and CWP.