The function of the CD4 coreceptor in the development of T cells.
The function of the CD4 coreceptor in the development of T cells.
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DOI：
10.3109/08830189509061735
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发表时间：
1995-01-01
影响因子：
5
通讯作者：
Littman, D R
中科院分区：
文献类型：
--
作者：
Killeen, N;Littman, D R
具有辅助活性的T细胞可以在缺乏CD 4糖蛋白表达的小鼠中发现。CD 4启动子在这些细胞中有活性;它们对MHC II类分子呈递的抗原有反应;它们不表达CD 8，并且它们的发育不依赖于MHC I类。根据这些标准，这些CD 8- T细胞类似于正常的CD 4+辅助性T细胞。通过表达编码野生型CD 4或CD 4缺失突变体的转基因可以增强CD 4缺失小鼠中辅助细胞系的发育，所述突变体缺乏胞质尾区，因此不能与酪氨酸激酶p56 lck相互作用。这些观察结果表明，CD 4不是绝对需要的辅助细胞谱系的规范。CD 4分子在T细胞发育中的作用及其实现其功能的可能机制进行了讨论。
T cells with helper activity can be found in mice that lack expression of the CD4 glycoprotein. The CD4 promoter is active in these cells; they respond to antigens presented by MHC class II molecules; they do not express CD8 and they do not depend on MHC class I for their development. By such criteria, these CD8- T cells resemble normal CD4+ helper T cells. The development of the helper lineage in CD4-null mice can be potentiated by expression of transgenes that encode either wild type CD4, or a deletion mutant of CD4 that lacks the cytoplasmic tail and therefore cannot interact with the tyrosine kinase p56lck. These observations suggest that CD4 is not absolutely required for the specification of the helper cell lineage. The role of the CD4 molecule in the development of T cells and possible mechanisms by which it achieves its functions are discussed.