The Use of the Panic and Agoraphobia Scale (P & A) in a controlled clinical trial
The Use of the Panic and Agoraphobia Scale (P & A) in a controlled clinical trial
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DOI：
10.1055/s-2000-12982
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发表时间：
2000-09-01
影响因子：
4.3
通讯作者：
R端ther, E
中科院分区：
文献类型：
--
作者：
Bandelow, B;Broocks, A;R端ther, E
工作背景：一个新的13项量表已经开发用于测量惊恐障碍和广场恐怖症患者的疾病严重程度，惊恐和广场恐怖症量表（P & A）。该量表有五个分量表，涵盖了降低惊恐障碍患者生活质量的主要因素（惊恐发作、回避、预期焦虑、残疾和对健康的担忧）。该量表在双盲安慰剂对照惊恐障碍试验中的应用。与此同时，本研究的目的是比较有氧运动的治疗效果与有充分证据证明的疗效。研究方法：惊恐障碍（DSM-IV）患者被随机分配到三种治疗方式：跑步（n = 45），氯丙咪嗪（n = 15）或安慰剂（n = 15）。使用恐慌和广场恐惧量表（P & A）和其他评定量表来测量治疗效果。结果如下：根据P & A和其他量表，与安慰剂治疗相比，运动和氯丙咪嗪均导致症状显著减轻。氯丙咪嗪明显更有效，改善焦虑症状显着早于运动。P & A分量表的评估显示，运动发挥其作用，主要是减少预期焦虑和恐慌相关的残疾。结论：新的惊恐和广场恐怖量表对不同惊恐治疗之间的差异敏感。分析量表的五个分项分数可能有助于了解惊恐障碍治疗的作用机制。
Background: A new 13-item scale has been developed for measuring severity of illness in patients with panic disorder and agoraphobia, the Panic and Agoraphobia Scale (P & A). The scale has five subscales covering the main factors that reduce quality of life in panic disorder patients (panic attacks, avoidance, anticipatory anxiety, disability and worries about health). The application of this scale in a double-blind placebo-controlled panic disorder trial is described. At the same time, the aim of the study was to compare the therapeutic effects of aerobic exercise with a treatment of well-documented efficacy. Methods: Patients with Panic disorder (DSM-IV) were randomly assigned to three treatment modalities: running (n = 45), clomipramine (n = 15) or placebo (n = 15). Treatment efficacy was measured with the Panic and Agoraphobia Scale (P & A) and other rating scales. Results: According to the P & A and other scales, both exercise and clomipramine led to a significant decrease of symptoms in comparison to placebo treatment. Clomipramine was significantly more effective and improved anxiety symptoms significantly earlier than exercise. The evaluation of the P & A subscales revealed that exercise exerted its effect mainly reducing anticipatory anxiew and panic-related disability. Conclusions: The new Panic and Agoraphobia Scale was shown to be sensitive to differences between different panic treatments. Analysis of the scales five subscores may help to understand mechanisms of action of panic disorder treatments.