Partial substitution of carbohydrate intake with protein intake from lean red meat lowers blood pressure in hypertensive persons
Partial substitution of carbohydrate intake with protein intake from lean red meat lowers blood pressure in hypertensive persons
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DOI：
10.1093/ajcn/83.4.780
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发表时间：
2006-04-01
影响因子：
7.1
通讯作者：
Puddey, IB
中科院分区：
文献类型：
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作者：
Hodgson, JM;Burke, V;Puddey, IB
背景：与碳水化合物摄入相比，人类饮食中摄入植物蛋白可以降低血压，但摄入动物蛋白对血压的影响尚不清楚。目的：我们的目的是确定从瘦红肉中摄取动物蛋白部分替代碳水化合物摄入是否会改变高血压患者的血压和其他心血管疾病风险指标。设计：高血压患者（n = 60）被招募到一个8周的平行设计研究中。参与者被随机分配，要么维持他们的日常饮食（对照组），要么用瘦红肉中的蛋白质部分替代从富含碳水化合物的食物中摄入的能量（蛋白质组）。在基线和干预结束时进行测量。结果：与对照组相比，蛋白质组的蛋白质摄入量显著增加[占能量的x（95% Cl）百分比：5.3% (3.7%,6.9%),P < 0.001]，相应的碳水化合物摄入量降低[占能量的-5.3% (-7.9%,-2.7%),P < 0.001]。两组之间的体重、脂肪、酒精和纤维摄入量没有显著差异。与对照组相比，蛋白质组临床、24小时、清醒、睡眠时收缩压均较低[-5.2（-10.37 -0.1）、-4.0（-7.4、-0.6）、-4.7（-8.9、-0.5）、-4.7(-10.3、-0.1)mm Hg, P < 0.05]，空腹血糖浓度较高[0.33 mmol/L(0.09、0.58 mmol/L), P = 0.008]。这些差异与年龄、性别、体重、酒精摄入量或尿钠钾排泄量的变化无关。两组间舒张压、心率、动脉顺应性、血脂、血清胰岛素均无显著差异。结论：在其他研究的背景下，这些结果表明，适度地用富含蛋白质的食物代替富含碳水化合物的食物可能会降低高血压患者的血压。
Background: Compared with carbohydrate intake, dietary intake of plant protein can lower blood pressure in humans, but the effects of animal protein intake on blood pressure have yet to be investigated.Objective: We aimed to determine whether partial substitution of carbohydrate intake with animal protein intake from lean red meat changes blood pressure and other markers of cardiovascular disease risk in hypertensive persons.Design: Hypertensive persons (n = 60) were recruited to an 8-wk parallel-design study. The participants were randomly assigned either to maintain their usual diet (control group) or to partially replace energy intake from carbohydrate-rich foods with protein from lean red meat (protein group). Measurements were performed at baseline and at the end of the intervention.Results: Compared with the control group, the protein group had a significantly higher protein intake [ x(95% Cl) percent of energy: 5.3% (3.7%, 6.9%), P < 0.001] and a corresponding lower carbohydrate intake [-5.3% of energy (-7.9%, -2.7%), P < 0.001]. Body weight and intakes of fat, alcohol, and fiber were not significantly different between the groups. Compared with the control group, the clinic, 24-h, awake, and asleep systolic blood pressures were lower [-5.2 (-10.37 -0.1), -4.0 (-7.4, -0.6), -4.7 (-8.9, -0.5), and -4.7 (-10.3, -0.1) mm Hg, respectively, P < 0.05] and fasting plasma glucose concentrations were higher [0.33 mmol/L (0.09, 0.58 mmol/L), P = 0.008] in the protein group. These differences were independent of age, sex, and changes in weight, alcohol intake, or urinary sodium and potassium excretion. Diastolic blood pressure and heart rate, arterial compliance, blood lipids, and serum insulin were not significantly different between the groups.Conclusion: Within the context of other studies, these results suggest that modest substitution of carbohydrate-rich foods with protein-rich foods may lower blood pressure in hypertensive persons.