Encephalitis With Antibodies Against the GABAB Receptor: High Mortality and Risk Factors
Encephalitis With Antibodies Against the GABAB Receptor: High Mortality and Risk Factors
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GABA(B) 受体抗体引起的脑炎：高死亡率和危险因素
DOI：
10.3389/fneur.2019.01030
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发表时间：
2019-09-26
影响因子：
3.4
通讯作者：
Hong, Zhen
中科院分区：
文献类型：
--
作者：
Lin, Jingfang;Li, Chen;Hong, Zhen
目的：测量抗γ-氨基丁酸B受体阳性患者的死亡率，确定死亡预测因子并调查死亡原因（抗GABA（B）R）脑炎。方法：前瞻性分析四川大学华西医院2013年6月至2018年8月诊断的抗GABA（B）R脑炎病例，评估死亡相关因素。结果：本研究共纳入28例（11例女性）抗GABA（B）R脑炎患者。在最长52个月（中位数11个月，范围2-52）的随访后，9例（32.1%）患者死亡，中位生存时间为6.5个月。5例患者死于肿瘤进展，1例患者死于惊厥性癫痫持续状态，1例患者死于感染性休克，2例患者死于重症肺炎。死亡的预测因素是发病年龄较大（P = 0.025），存在肿瘤（66.7 vs. 15.8%，P = 0.013），并发症数量（2.6 vs. 1.0，P = 0.009）和深静脉血栓形成结论：GABA（B）R脑炎患者5年内病死率高。发病年龄大、有肿瘤、并发症多、深静脉血栓形成与死亡有关。
Objective: To measure mortality, identify predictors of death and investigate causes of death in patients with anti-gamma-aminobutyric-acid B receptor (anti-GABA(B)R) encephalitis.Methods: Prospective analysis of anti-GABA(B)R encephalitis cases diagnosed between June 2013 and August 2018 in West China Hospital of Sichuan University, with assessment of factors associated with mortality.Results: A total of 28 patients (11 females) with anti-GABA(B)R encephalitis were included in this study. After a maximum time of 52 months (median 11 months, range 2-52) of follow-up, 9 (32.1%) patients died, with a median survival time of 6.5 months. Five patients died of tumor progression, one patient died of convulsive status epilepticus, one patient died of septic shock, and two patients died of severe pneumonia. Predictors of death were older age at onset (P = 0.025), presence of a tumor (66.7 vs. 15.8%, P = 0.013), the number of complications (2.6 vs. 1.0, P = 0.009) and deep venous thrombosis (33.3% vs. 0, P = 0.026).Conclusion: Patients with GABA(B)R encephalitis have a high mortality rate within 5 years. Older age at onset, presence a tumor, the number of complications, and deep venous thrombosis are associated with death.