EFFECT OF ESTRADIOL ON TISSUE GLYCOGEN-METABOLISM AND LIPID AVAILABILITY IN EXERCISED MALE-RATS
EFFECT OF ESTRADIOL ON TISSUE GLYCOGEN-METABOLISM AND LIPID AVAILABILITY IN EXERCISED MALE-RATS
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DOI：
10.1152/jappl.1991.71.5.1694
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发表时间：
1991-11-01
影响因子：
3.3
通讯作者：
ELLIS, GS
中科院分区：
文献类型：
--
作者：
KENDRICK, ZV;ELLIS, GS
在雄性大鼠中测定17-β-雌二醇3-苯甲酸酯（10 μ g，0.1ml向日葵油-1.100g体重-1）对运动表现、组织糖原利用和脂质利用的影响。 在实验1中，雌二醇或油在跑步机跑步至力竭前1小时或1-6天给药。 在6天给药期间，未观察到油和雌二醇给药动物之间的体重差异。 接受雌二醇3-6天的动物比油给药的动物跑得更长，完成更多的工作。 在所有跑至力竭的动物中观察到红色和白色股肌、心肌和肝糖原显著降解。 在实验2中，动物给予雌二醇5天，然后跑2小时。 次极量运行2小时显著降低了油给药动物的红色和白色股肌、心脏和肝脏中的组织糖原含量。 后一种效应在给予雌二醇的动物的股肌、肝脏和心肌组织中减弱。 在次极量跑步过程中，给予依地平显著增加血浆脂肪酸并降低血浆乳酸。 这些数据表明，当雄性大鼠组之间的体重保持不变时，雌二醇给药3-6天增加了运动表现。 此外，雌激素给药5天导致更大的脂质利用率和更少的组织糖原利用率在亚极量运行2小时。
The effect of 17-beta-estradiol 3-benzoate (10-mu-g.0.1 ml sunflower oil-1.100 g body wt-1) on exercise performance, tissue glycogen utilization, and lipid availability was determined in male rats. In experiment 1, estradiol or oil was administered 1 h or 1-6 days before a treadmill run to exhaustion. No differences in body weight between oil- and estradiol-administered animals were observed during the 6-day treatment. Animals receiving estradiol for 3-6 days ran significantly longer and completed more work than oil-administered animals. Significant degradation of red and white vastus muscle, myocardial, and liver glycogen was observed in all animals run to exhaustion. In experiment 2, animals were administered estradiol for 5 days and then run for 2 h. The submaximal run for 2 h significantly reduced tissue glycogen content in red and white vastus muscle, heart, and liver of oil-administered animals. The latter effect was attenuated in both vastus muscles, liver, and myocardial tissues in the estradiol-administered animals. Estradiol administration significantly increased plasma fatty acids and lowered plasma lactate during the submaximal run. These data indicate that when body weight remained constant between groups of male rats, estradiol administration for 3-6 days increased exercise performance. Furthermore, estradiol administration for 5 days resulted in greater lipid availability and less tissue glycogen utilization during submaximal running for 2 h.