Aiming for a Better Understanding and Management of Cancer-Related Fatigue
Aiming for a Better Understanding and Management of Cancer-Related Fatigue
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DOI：
10.1634/theoncologist.2013-0076
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发表时间：
2013-10-01
期刊：
影响因子：
5.8
通讯作者：
Verheul, Henk M. W.
中科院分区：
文献类型：
--
作者：
Neefjes, Elisabeth C. W.;van der Vorst, Maurice J. D. L.;Verheul, Henk M. W.
癌症相关性疲劳（CRF）是癌症患者的一种严重症状，会降低他们的日常生活质量。虽然疲劳是一般人群中的一个常见问题，患病率约为 30%，但高达 99% 的癌症患者有更严重的疲劳。 CRF与癌症的生物学特性直接相关，但也与抗癌治疗有关。我们回顾了有关导致 CRF 的潜在病理生理机制的当前证据。将讨论确定 CRF 的存在和严重程度的临床方法以及减少 CRF 的潜在治疗方案。阅读这篇综述后，读者将了解当前对 CRF 的理解，并能够为 CRF 患者提供基于证据的建议。
Cancer-related fatigue (CRF) is a serious symptom of patients with cancer and deteriorates their daily quality of life. Whereas fatigue is a common problem in the general population, with a prevalence of about 30%, up to 99% of patients with cancer have fatigue of more intense severity. CRF is directly related to the biology of cancer, but it can also becaused by anticancer treatment. We reviewed current evidence about the potential pathophysiological mechanisms causing CRF. Clinical methods to determine the presence and severity of CRF and potential treatment options to reduce CRF will be discussed. After reading this review, the reader will have knowledge of the current understanding of CRF and will be able to give evidence-based advice to patients with CRF.